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Effects of Pineapple Juice and Ginger Drink for Relieving Primary Dysmenorrhea Pain among Adolescents

Dita Wrisnijati, Budiyanti Wiboworini, Sugiarto Sugiarto

Abstract

Background: Primary dysmenorrhea is characterized by low abdominal pain occurring during menstruation. It is negatively impact on all aspects of life of adolescents such as increased school absteeinsm, emotional disorders, impaired social interaction and productivity. The herbal drink which they can self-prepared is common choice as home remedies to relieve the pain. This study aimed to examine the effect of pineapple juice and ginger drink in providing pain relief to the adolescent with primary dysmenorrhea.

Subjects and Method: This was a randomized trial study conducted at three high schools in Surakarta, Central Java, Indonesia, from January to April 2018. A sample of 39 female students aged 15-17 years was selected for this study, divided into three groups. The treatment was given for 3 days from first day of menstruation for 3 menstruation cycles. The pain score were measured by numeric rating scale (NRS). The data were analyzed by Mann-Whitney.

Results: Pain score in pineapple juice group (mean= 2.25; SD= 1.79) and ginger drink group (mean= 3.63; SD= 2.02) were lower than control group (mean= 5.64; SD= 1.25) and it was statistically significant.

Conclusion: Pineapple juice and ginger drink effective to reduce pain of primary dysmenorrhea among female adolescent.

Keywords: Dysmenorrhea, pain, pineapple juice, ginger drink, female adolescents

Correspondence: Dita Wrisnijati. Masters Program in Nutrition, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. E-mail: ditawrisnijati@gmail.com. Mobile: (62)85742916542.

Indonesian Journal of Medicine (2019), 4(2): 96-104
https://doi.org/10.26911/theijmed.2019.04.02.03

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References

Agostinis C, Zorzet S, De Leo R, Zauli G, De Seta F, Bulla R (2015). The combination of N-Acetyl cysteine, Alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of Endo-metriosis. Mediator of Inflammation, 2015: 1-9.

Al-Asadi JN, Abdul-Quadir RA (2013). Dys-menorrhoea and its impact on daily routine activities among secondary school students in Basra, Iraq. J Fac Med Baghdad, 55 : 339-344.

Ali BH, Blunden G, Tanira MO, Nemmar A (2008). Some phytochemical, pharmacological dan toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chemical Toxicology, 46(2): 409–420.

Bernardi M, Lazzeri L, Perelli F, Reis FM, Petraglia F (2017). Dysmenorrhea and related disorders: Review. F1000research, 6: 1-7.

Bhui K, Prasad S, George J, Shukla Y (2009). Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway. Cancer Lett, 282: 167-176.

Bolten WW, Glade MJ, Raum S, Ritz BW (2015). The safety and efficacy of an enzyme combination in managing knee osteoarthritis pain in adults: A randomized, double-blind, placebo-controlled trial. Arthritis, 25: 15-21.

Contreras A, Paape MJ, Miller RH, Corrales JC, Luengo C, Sanchez A (2008). Effect of bromelain on milk yield, milk composition, dan mammary health in dairy goats. Tropical Animal Health Production, 41: 493-498.

Chen CX, Barrett B, Hindawi KLK (2016). Efficacy of Oral Ginger (Zingiber officenale) for Dysmenorrhea: A Systematic Review and Meta-Analysis. Publishing Corporation Evidence-Based Complementary and Alternative Medicine, 57: 1-10.

Dighe NS, Pattan SR, Merekar AN, Laware RB, Bhawar SB, Nirmal SN, Gaware VM, Hole MB, Musmade DS (2010). Bromelain A Wonder Supplement: A Review. Pharmacologyonline, 1: 11-18.

Dugasani S, Pichika MR, Nadarajah VD, Balijepalli MK, Tandra S, Korlakunta JN. 2010. Comparative antioxidant and anti-inflammatory effects of [6]gingerol, [8]gingerol, [10]gingerol and [6]shogaol. Journal of Ethnopharmacology, 127: 515–520.

Fatima A, Mamatha KR, Ambika B, Rajarathna K (2017). Self-medication practice in primary dysmenorrhea among medical and paramedical students A cross-sectional questionnaire study. National Journal of Physiology, Pharmacy and Pharmacology, 7(5): 458-463.

Hidayat R (2010). Efek analgesik dan anti-inflamasi jus buah nanas (Ananas comosus) pada mencit betina galur swiss. Thesis. Sanata Dharma University, Yogyakarta.

Hirche C, Citterio A, Hoeksema H, Koller J, Lehner M, Martinez JR, Monstrey S, et al. (2017). Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus. Burns, 17: 19-29.

Jayachandran S, Khobre P (2017). Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes dan Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis A Randomised Clinical Trial. Journal of Clinical Diagnosis Respiratory, 11 (6): 9-11.

Jenabi E (2013). The effect of ginger for relieving of primary dysmenorrhea. Journal of the Pakistan Medical Association, 63 (1): 8–10.

Jung HW, Yoon CH, Park KM, Han HS, Park YK (2009). Hexane fraction of Zingiberis Rhizoma Crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF kappaB pathway. Food Chemical Toxicology, 47: 1190–1197.

Latha S, Venketesan L (2016). Effectiveness of Ginger tea on dysmenorrhea among college student. International Journal of Applied Research, 2 (12): 669-671.

Leelavathi S, Hemavathy V (2015). Effectiveness of Ginger Remedy on Dysmenorrhea. International Journal of Innovative Research in Science, Engineering and Technology, 4 (5): 2904-2908.

Madhubala C, Jyoti K (2012). Relation between dysmenorrhea dan body mass index in adolescents with rural versus urban variation. The Journal of Obstetrics dan Gynecology of India, 62 (4): 442-445.

Mohamed SIA, Jantan I, Haque MA (2017). Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action. International Immunopharmacol, 50: 291-304

Muhammad ZA, Ahmad T (2017). Therapeutic uses of pineapple-extracted bromelain in surgical care A review. J Pak Med Assoc, 67 (1) :121-125

Müller S, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P (2013). Placebo-controlled randomized clinical trial on the immunemodulating activeties of low- and high-dose bromelain after oral administration- new evidence on the anti-inflammatory mode of action of bromelain. Phytotherapy Research, 27(2): 199-204.

Onken JE, Greer PK, Calingaert B, Hale LP (2008). Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clinical Immunology, 126: 345-352.

Ozgoli G, Goli M, Moattar F (2009). Comparison of effects of ginger, mefenamic acid, dan ibuprofen. on pain in women with primary dysmenorrhea. Journal of Alternative dan Complementary Medicine, 15(2): 129–132.

Pan MH, Hsieh MC, Kuo JM, Lai CS, Wu H, Sang S (2008). [6]Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular Nutrition and Food Research, 52: 527–537.

Pavan R, Jain S, Shraddha, Kumar A (2012). Properties and Therapeutic Application of Bromelain: A Review. Biotechnology Research International, 9 : 203-208

Rahnama P, Montazeri A, Huseini HF, Kianbakht S, Naseri M (2012). Effect of Zinger officinale R. rhizomes (ginger) on pain relief in primary dysmenorrhea: A placebo Randomized trial. BMC Complementary dan Alternative Medicine, 12(92): 1-8.

Ramya S, Vasundara K, Suvarna, Pundarikaksha HP, Prathap B, Gladius JH, et al (2014). A prospective study of the pattern of drug use in primary dysmenorrhoea in a tertiary care hospital. Int J Res Pharmacol Pharmacotherapy, 3(1): 80-84.

Rathnavelu V, Alitheen NB, Sohila S, Kanagesan S, Ramesh R (2016). Potential role of bromelain in clinical dan therapeutic applications (Review). Biomedical Reports, 5: 283-288.

Rodrigues S, Gomes W, Ferndanes FAN (2017). Effect of acoustically assisted treatments on vitamins, antioxidant activity, organic acids dan drying kinetics of pineapple. Ultrason Sonochem, 35: 92-102.

Sahbaz A, Aynioglu O, Isik H, Ozmen U, Cengil O, Gun BD, Gungorduk K (2015). Bromelain: A natural proteolytic for intraabdominal adhesion prevention. International Journal of Surgery, 14: 7 – 11.

Santoro NF, Neal-Perry G (2010). Amenorrhea: A case-Based, Clinical Guide Contemporary endocrinology. Springer Science Business Media LLC, Berlin.

Shirvani MA, Motahari-Tabari N, Alipour A (2014). Use of ginger versus stretching exercises for the treatment of primary dysmenorrhea: A Randomized controled trial. Journal of Integrative Medicine, 15 (4): 295–301.

Singh T, More V, Fatima U, Karpe T, Aleem MA, Prameela J (2016). Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars. Journal of International society of preventive and community dentistry, 6 (3): 197–204.

Sorice A, Guerriero E, Capone F, Colonna G, Castello G, Constantini S (2014). Ascorbic acid: Its role in Immune System and Chronic Inflammation Diseases. Mini-review in Medicinal Chemistry, 14 (5): 1-9.

Sowjanya K, Spandana U, Manjula RR, Havilah E, Sravani T, Shiva G, Nageswara, R (2016). Wound healing activity dan anti-ulcer activity of ethanolic extract of peels of Ananas comosus. European journal of pharmaceutical dan medical research, 3(3): 417-422.

Tadikonda A, Pentapati KC, Urala AS, Acharya S (2017). Anti-plaque dan anti-gingivitis effect of Papain, Bromelain, Miswak dan Neem containing dentifrice: A Randomized controlled trial. Journal Clinical Experimental Dental, 9(5): 649-653.

Tap FM, Majid FAA, Ismail HF, Wong TS, Shameli K, Miyake M, Khairudin NBA (2018). In Silico and In Vitro Study of the Bromelain-Phytochemical Complex Inhibition of Phospholipase A2 (Pla2). Molecules, 23 (73): 1-13.

Wallace S, Keightley A, Gie C (2010). Dysmenorrhoea. The Obstetrician & Gynaecologist, 12 : 149–154.

Wong CL, Farquhar C, Roberts H, Proctor M (2009). Oral contraceptive pill as treatment for primary dysmenorrhoea. Cochrane Database of Systematic Reviews, 7(4) : 1-10

Zhou Z, Wang L, Feng P, Yin L, Wang C, Zhi S, Dong J, et al. (2017). Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis. Frontiers in Immunology, 8: 1468-1474.

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