The Relationship of Radiological Value and Functional Scale of Lower Motion Devices in Patients with Bone Defects Given Synthetic Bone Graft and BMP2

Farid Ibrahim, Ismail Mariyanto, Hari Wujoso


Background: Broken bones in a severe lower motion device, especially those associated with a bone defect, often fail or are slow to fuse. The possibility of non-union in patients triggering clinicians to use bone-grafting as part of a procedure aims at achieving the union. The Gold Standard is to use autogenous bone graft, but it actually has some disadvantages. To overcome this, there are alternative measures of bone grafting. Hydroxyapatite is known to be synthetic bonegraft which has good osteoconductive properties. For hydroxyapatite, it has been widely used and easily available. Bone morphogenetic proteins (BMPs) are the family of osteo-inductive proteins in the bone matrix. This study aims to evaluate the effectiveness of synthetic bone graft and BMP-2 as a bonegraft in the process of bone healing with "bone defect" in long bones by evaluating the process of radiological closure of defects and clinical bone healing process.

Subjects and Method: This was a cross sectional study. A sample of 20 patients with bone defect in the tibia and femur was selected for this study. An evaluation of radiological defect closure was evaluated using a calculation system using the FDA-determined radiological evaluation method and a periodic lower function of the LEFS (Lower Extremity Functional Scale) every 2 months up to the 6th month. The statistical tests were performed using linear regression.

Results: There is a negative relationship between the radiological value and the functional scale of the lower motion device (b = -1.26; p = 0.001). There is an improvement in bone defect closure and clinical functional improvement in patients who performed a synthetic bonegraft closure action added by BMP-2 as well. The evaluation is carried out through radiological calculations that show a periodically reduced size of the defect which affects the increase in the value of the functional scale of the lower motion device.

Conclusions: There is a negative relationship between radiological values and functional scale of lower motion devices in patients with bone defect in the tibia bone or femur given synthetic bone graft and Bmp2.

Keywords: bone defects, synthetic bone grafts and BMP-2, LEFS

CorrespondenceFarid Ibrahim. Masters Program in Family Medicine, Universitas Sebelas Maret, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java.

Indonesian Journal of Medicine (2018), 3(2): 77-83

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