Survival Predictors of People Living with HIV/ AIDS in Wamena, Papua
Abstract
Background: Quality of life (QoL) is an important component in the evaluation of the well-being of people living with HIV and AIDS (PLWHA), especially with the appreciable rise in the longevity of PLWHA. The analysis of the quality of life is essential for the healthcare policies and services directed toward PLWHA, since this indicator values the perception of people about their own life and health. However, little is known about the determinant of QoL in PLWHA in Papua. The aim of this study was to analyze survival predictors of people living with HIV/ AIDS in Wamena, Papua, Indonesia.
Subjects and Method: This was a retrospective cohort study conducted in Wamena Hospital, Papua, from December 2017 to February 2018. A cohort of 304 PLWHA was selected for this study from the medical record at Wamena Hospital. The dependent variable was survival. The independent variables were adherence to ART, nutritional status, age, and coinfection. The data were collected from medical record and questionnaire. The data were analyzed by Cox regression model.
Results: The risk of dying of PLWHA if adherent to take the ART was lower than not adherent to take the ART (HR=0.45; 95% CI= 0.06 to 0.33; p= 0.002).The risk of dying of PLWHA with poor nutritional status was higher than good nutritional status (HR= 12.78; 95% CI= 6.81 to 23.98; p< 0.001). The risk of dying of PLWHA aged ?35 years was slightly higher than <35 years (HR= 1.47; 95% CI= 1.00 to 2.17; p= 0.050). The risk of dying of PLWHA with coinfected was higher than without coinfected (HR= 1.59; 95% CI= 1.15 to 2.23; p= 0.006).
Conclusion: The risk of dying of PLWHA decreases if adherent to take the ART, but increases with poor nutritional status, age ?35 years, and coinfection.
Keywords: survival, adherence to treatment, people living with HIV/ AIDS.
Correspondence:
References
Arjun BY, Unnikrishnan B, Ramapuram JT, Thapar R, Mithra P, Kumar N, Madi D et al. (2015)
Arts EJ, Hazuda DJ (2012). HIV 1 antiretroviral drug therapy
Bacheler LT, Anton ED, Kudish P, Baker D, Bunville J, Krakowski K, Bolling L. et al. (2000)
Boulougoura A, Sereti I (2016)
Boyer PL, Sarafianos SG, Arnold E, Hughes SH (2001)
Dorr P, Westby M, Dobbs S, Griffin P, Irvine B, Macartney M, Mori J. (2005)
Dykes C, Fox K, Lloyd A, Chiull Mi, Morse E, Demeter LM. (2001)
Hasanah CI, Zaliha AR, Mahiran M. (2011)
Hendricks KM, Erzen HD, Wanke CA, Tang AM. (2010)
Iacob SA, Iacob DG, and Jugulete G. (2017)
KaiserJD, Campa AM, Ondercin JP, Leoung GS, Pless RF, Baum MK. (2006)
Kemenkes Republik Indonesia (2016). Situasi penyakit HIV AIDS di Indonesia, Pusat Data dan Informasi Kementerian Kesehatan RI.
Kementerian Kesehatan Republik Indonesia Direktorat Jenderal Pengendalian Penyakit dan Penyehatan Lingkungan. (2011) Pedoman Nasional Tatalaksana Klinis Infeksi HIV dan Terapi Antiretroviral pada Orang Dewasa.
Kirkcaldy EM, Spiegel P, Abdalla F, Erdelmann F (2006)
Lalezari JP, Henry K, O'Hearn M, Montaner JSG, Piliero PJ, Trottier B, Walmsley S. et al. (2003)
Lewandowski CM, Coinvestigator N, Lewandowski CM (2015) WHO Glocal tuberculosis report 2015, The effects of a brief mindfulness intervention on acute pain experience: An examination of individual difference.
Lodi S, Phillips A, Touloumi G, Geskus R, Meyer L, Thi
Naeger LK, Margot NA, Miller MD (2002)
Oguntibeju OO. (2012)
Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM. et al. (2000)
Rathbun C (2017) Antiretroviral Therapy for HIV Infection, Medscape.
Riourd ML, Ehresmann C, Parniak MA, Ehresmann B, Marquet R (2002)
Schey KL, Luther JM, Rose KL (2016)
Shafer RW, Rhee SY, Pillay D, Miller V, Sandstrom P, Schapiro JM, Kuritzkes DR et al. (2007)
SluisCremer N, Temiz NA, Bahar I (2004)
Sullivan ZA, Wong EB, Ndung'u T, Kasprowicz VO, Bishai WR. (2015)
UNAIDS (2015) Global Aids Response Progress Reporting 2015, The Lancet.
Unit B, Africa S (2009).
Veazey RS, Klasse PJ, Schader SM, Hu Q, Ketas TJ, Lu M, Marx PA. et al. (2005)
Who and Searo (2008)
Wilen CB, Tilton JC, Doms RW (2012)
Zanoni BC, Gandhi R T (2014)
