Relationship of Neutrophil Lymphocyte Ratio and Glomerulus Filtration Rate in Diabetic Nephropathy Patients at H. Adam Malik Hospital, Medan, Indonesia
DOI:
https://doi.org/10.26911/theijmed.2024.09.01.03Abstract
Background: Diabetic nephropathy is a serious complication of diabetes mellitus (DM). The neutrophil-lymphocyte ratio is the result of the relative count of neutrophils divided by the relative number of lymphocytes in diabetic nephropathy patients in % units obtained from routine hematology results using EDTA blood samples and measured by flow cytometry with Sysmex XN-1000, glomerular filtration rate was measured according to the Cockroft-Gault formula. This study aimed to determine the relationship between neutrophil lymphocyte ratio (NLR) and glomerular filtration rate in diabetic nephropathy patients.
Subjects and Method: This was a cross sectional study conducted at H. Adam Malik Hospital, Medan, North Sumatera, Indonesia, from November 2022 – January 2023. 30 diabetic nephropathy patients were selected for this study consecutively. The dependent variable was the glomerular filtration rate. The independent variable was the NLR. Blood sample was taken for a complete blood count and creatinine examination. Data were analyzed using the Spearman test.
Results: NLR was negatively associated with eGFR in patients with diabetic nephropathy, but it was statistically non significant (r= -0.25; p= 0.186).
Conclusion: NLR is negatively associated with eGFR in patients with diabetic nephropathy, but it is statistically non significant.
Keywords: neutrophil lymphocyte ratio, glomerular filtration rate, diabetic nephropathy
References
Adnyani PY, Mahartini NN, Herawati S, Mulyantari NK, Lestari AAW (2021). Comparison of Neutrophil to Lymphocyte Ratio (NLR) and Lymphocyte to Monocyte Ratio (LMR) values in controlled and uncontrolled Type 2 Diabetes Mellitus (T2DM) patient. Bali Medical Journal 10(2): 798801. DOI: 10.15562/bmj.v10i2.2501
Azikin A, Mangarengi F, Bahrun U (2018). Relationship Between Neutrophil – Lymphocytr Ratio and Decreased Glomerular Filtration Rate In Diabetic Majalah Patologi Klinik Indonesia dan Laboratorium Medik. 24(2): 131135 .
Chewcharat A, Chewcharat P, Rutirapong A, Papatheodorou S. (2020). The effects ofomega3 fatty acids on diabetic nephropathy: A metaanalysis of randomized controlled trials. DOI: 10.1371/journal.pone.0228315.
Dabla PK (2019). Renal function in diabetic nephropathy. World J Diabetes. 1(2): 4856. doi: 10.4239/wjd.v1.i2.48.
Erny K, Makmur MJ, Aras RBP (2020). Karakteristik Faktor faktor risiko terjadinya komplikasi kronik nefropati diabetic dan atau penyakit pembuluh darah perifer pada penderita diabetes mellitus di RSUD Raden Mattaher Tahun 2018. Electronic Journal Scientific of Envitonmental Health And Diseases (eSEHAD). 2(1): 1932. https://doi.org/10.22437/esehad.v1i1.10761.
Fawwad A, Butt AM, Siddiqui IA (2018). Neutrophiltolymphocyte ratio and microvascular complications in subjects with type 2 diabetes: Pakistan’s perspective. DOI : 10.3906/sag1706141.
Khandare SA, S Chittawar, et al. (2017). Study of neutrophillymphocyte ratio as novel marker for diabetic nephropathy in type 2 diabetes. International Urology and Nephrology. 51(7): 1239–1247. DOI: 10.4103/ijem.IJEM_476_16.
Kothai, Neha K, Bholenath Patil A, et al. (2020). Neutrophil lymphocyte ratio as a marker of diabetic nephropathy. J. Evid. Based Med. Healthc. DOI: 10.1111/cen.12576.
Heng Wan, Yuying Wang, Sijie Fang. (2020). Associations between the Neutrophil toLymphocyte Ratio and Diabetic Complications in Adults with Diabetes: A CrossSectional Study. https://doi.org/10.1155/2020/6219545.
Park HC, Lee YK, Cho A, Han Ch, Noh JW, Shin YJ, et al. (2019). Diabetic retinopathy is a prognostic factor for progression of chronic kidney disease in the patients with type 2 diabetes mellitus. PLoS ONE 14(7): e0220506. DOI: 10.1371/journal.pone.0220506.
Ren X, Kang N, Yu X, Li X, Tang Y, Wu J. Prevalence and association of diabetic nephropathy in newly diagnosed Chinese patients with diabetes in the Hebei province: A singlecenter casecontrol study. Medicine. 11(e32911).
Yoshitomi R, Nakayama M, et al. (2019). High neutrophil/lymphocyte ratio is associated with poor renal outcomes in Japanese patients with chronic kidney disease. Ren Fail. 41(1):238243. doi: 10.1080/0886022X.2019. 1595645.
Zhang R, Chen J, et. al. (2022). Increased neutrophil count Is associated with the development of chronic kidney disease in patients with diabetes. J Diabetes. 14(7):442454. doi: 10.1111/17530407.13292.
