Meta Analysis the Effect of Cadmium Exposure on Chronic Renal Filure in Adults
Abstract
Background: Heavy metals, such as cadmium, are heavy metals that are hazardous to health. Chronic exposure to cadmium is associated with decreased glomerular filtration rate and increased risk of chronic renal failure. This study was conducted to determine how much influence cadmium exposure has on the incidence of chronic kidney failure in adults. The purpose of this study was to analyze the effect of cadmium exposure on the incidence of chronic kidney failure in adults.
Subject and Method: This study is a systematic review and meta-analysis using the PRISMA flowchart with PICO as follows, Population: Adults. Intervention: Exposure to Cadmium. Comparison: No Cadmium Exposure. Outcome: Chronic Renal Failure. Search articles using several databases including PubMed, Google Scholar, and Science Direct with the search keywords “adults” AND “cadmium exposure” AND “chronic kidney failure”. The articles submitted ranged from 2013 to 2021. Analysis was performed using RevMan 5.3 as a statistical program.
Results: There are 11 articles, originating from the continents of Asia and Europe. The results of the meta-analysis showed that exposure to cadmium increased the risk of developing chronic renal failure in adults by 2.81 times compared with adults who were not exposed to cadmium and was statistically significant (aOR = 2.81; 95% CI = 1.74 to 4.51; p < 0.001).
Conclusion: Cadmium exposure may increase the risk of chronic kidney failure in adults.
Keywords: cadmium, chronic renal failure, adults
Correspondence: Fathia Mutiara Zahra. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: efemzahra31@student.uns.ac.id. Mobile: +62 815-6798-7661.
Indonesian Journal of Medicine (2022), 07(01): 61-72
https://doi.org/10.26911/theijmed.2022.07.01.07
References
Akerstrom M, Sallsten G, Lundh T, Barregard L (2013). Associations between urinary excretion of cadmium and proteins in a nonsmoking population: renal toxicity or normal physiology?. J Environ Health Perspect. 121: 187–191.
Anupama YJ, Kiran SK, Hedge SN (2019). Heavy metals and pesticides in chronic kidney disease results from a matched casecontrol in South India. Indian. J Nephrol. 29(6): 402409. DOI: 10.4103/ijin.IJIN_325_18.
Byber K, Lison D, Verougstraete V, Dressel H, Hotz P (2015). Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review. Crit Rev Toxicol. 46(3): 191–240. doi: 10.3109/10408444.2015.1076375.
Chen X, Chen X, Wang X, Wang M, Liang Y, Zhu G, Jin T (2021). The association between estimated glomerular filtration rate and cadmium exposure: An 8year followup study. Int J Hyg Environ Health, 235: 1438–4639. doi: 10. 1016/j.ijheh.2021.113774.
Chung S, Chung JH, Kim SJ, Koh ES, Yoon HE, Park CW, Koh ES, et al. (2013). Blood lead and cadmium levels and renal function in Korean adults. J Clin Exp Nephrol. DOI 10.1007/s1015701309136.
Dewi CH (2020). Perbedaan kadar cadmium (Cd) dalam darah dan tekanan darah pada pengelas dan non pengelas di PT X Surabaya (Differences in blood cadmium (Cd) levels and blood pressure on welders and nonwelders at PT X Surabaya). J. Wiyata. PISSN 23556498,EISSN 24426555.
Ferraro PM, Costanzi S, Naticchia A, Sturniolo A, Gambaro G (2010). Low level exposure to cadmium increases the risk of chronic kidney disease: analysis of the NHANES 19992006. BMC Public Health. 10(304):18.
GrauPerez M, Pichler G, GalanChilet I, BriongosFiguero LS, RenteroGarrido P, LopezIzquierdo R, NavasAcien A, et al. (2017). Urine cadmium levels and albuminuria in a general population from Spain: A geneenvironment interaction analysis. J Environ Int. 106: 27–36. doi: 10. 1016/J.ENVINT.2017. 05.008.
Hellstrom L, Elinder CG, Dahlberg B, Jarup L, Persson B, Axelson O (2001). Cadmium exposure and endstage renal disease. Am J Kidney Dis. 38(5): 10011008. doi: 10.1053/ajkd.2001.28589.
Hsueh YM, Huang YL, Lin YF, Shiue HS, Lin YC, Chen HH (2021). Plasma Vitamin B12 and folate alter the association of blood lead and cadmium and total urinary arsenic levels with chronic kidney disease in a Taiwanese population. J. Nut. 13, 3841. doi:10. 3390/nu13113841.
Hwangbo Y, Weaver VM, TellezPlaza M, Guallar E, Lee B, NavasAcien A (2011). Blood cadmium and estimated glomerular foltration rate in Korean adults. J Environ Health Perspect. 119.
Jain RB (2020). Cadmium and kidney function: Concentrations, variabilities, and associations across various stages of glomerular function. J Environ Pollut. 256: 113361. doi: 10.1016/J.ENVPOL.2019.113361.
Kim NH, Hyun YY, Lee KB, Chang Y, Rhu S,Oh KH, Ahn C (2015). Environmental heavy metal exposure and chronic kidney disease in the general population. J. Korean. Med. Sci. doi: 10.3346/jkms.2015.30.3.272.
Lyu YB, Zhao F, Qiu YD, Ding L, Qu YL, Xiong JH, Lu YF et al. (2021). Association of cadmium internal exposure with chronic kidney disease in Chinese adults. Europe PMC. 101: 19211928. DOI: 10.3760/cma.j. cn1121372021042500996.
Madrim MF, Ja'afar, Hod R (2021). Prevalence of abnormal urinary cadmium and risk of albuminaria as a primary bioindicator for kidney problems among a healthy population. PeerJ. doi: 10.7717/ peerj.12014.
Mariadi PD, Kurniawan I, Anita T, Ngole BB (2021). Penggunaan darah sebagai biomarker paparan logam cadmium masyarakat pesisir Sungai Musi (efek eritrosit dan leukosit) (The use of blood as a biomarker of cadmium metal exposure in coastal communities
of the Musi River (effect of erythrocytes and leukocytes). J Mat Sci Nat. https://jurnal.univpgripalembang.ac.id/index.php/sainmatika.
Permenkes (2017). Standar Baku Mutu Kesehatan Lingkungan dan Persyaratan Kesehatan Air Untuk Higiene Sanitasi, Kolam Renang, Solus Per Aqua, dan Permandian Umum (Environmental Health Quality Standards and Water Health Requirements for Sanitary Hygiene, Swimming Pools, Solus Per Aqua, and Public Baths). https: //peraturan.bpk.go.id/Home/Details/112092/permenkesno32tahun2017. Accessed at 7 Juni 2022.
Satarug S, Ruangyuttikarn W, Nishijo M, Ruiz P (2018). Urinary cadmium threshold to prevent kidney disease development. J. Toxics. 6(26):114. doi:10.3390/toxics6020026.
Shi Z, Taylor AW, Riley M, Byles J, Liu J, Noakes M (2018). Association between dietary pattern, cadmium intake and chronic kidney disease among adults. J. Clin. Nut. 31: 276284. doi: 10.1016/j.clnu.2016.12.025.
Sommar JN, Svensson M, Bjor BM, Elmstahl SI, hallmans G, Lundh T, Schon SM, et al. (2013). Endstage renal disease and low level exposure to lead, cadmium and mercury; a populationbased, prospective nested casereferent study in Sweden. J Environ. Health. 12(9): 110.
Tsai KF, Hsu PC, Kung CT, Lee CT, You HL, Huang WT, Li SH, et al. (2021). The risk factors of blood cadmium elevation in chronic kidney disease. J Environ. Res Public Health. 18(12337) : 114. doi: 10.3390/ijerph182312337.
Wang D, Sun H, Wu Y, Zhou Z, Ding Z, Chen Xiaodong, Xu Y (2016). Tubular and glomerular kidney effects in the Chinese general population with low environmental cadmium exposure. J. Chemospere. 147: 38. doi: 10.1016 /j.chemosphere.2015.11.069.
Wang X, Cui W, Wang M, Liang Y, Zhu G, Jin, T, Chen X (2021). The Association between lifetime dietary cadmium intake from rice and chronic kidney diasease. J. Eco. Environ. Safety. 211: 17. doi:10.1016/j.ecoenv.2021.111933.
Wu CY, Wong CS, Chung CJ,Wu MY, Huang YL, Ao PL, Lin YF, et al. (2019). The association between plasma selenium and chronic kidney disease related to lead, cadmium and arsenic exposure in a Taiwanese population. J Haz Mat. 375: 224232. doi: 10/1016/j.jhazmat.2019.04.082.
Zhu XJ, Wang JJ, Mao JH, Shu Q, Du LZ (2019). Relationships of Cadmium, Lead, and Mercury Levels With Albuminuria in US Adults: Results From the National Health and Nutrition Examination Survey Database, 2009–2012. Am. J. Epidemiol. 188(7): 1281–1287. doi:10.1093/AJE/KWZ070.
