Effect of Zingiber officinale Rhizome Powder on Fasting Blood Sugar Levels and HbA1c in Type 2 Diabetes Mellitus Patients: A Meta-Analysis


  • Fajar Novianto Masters of Public Health, Universitas Sebelas Maret
  • Didik Gunawan Tamtomo Faculty of Medicine, Universitas Sebelas Maret
  • Hanung Prasetya Study Program of Acupuncture, Health Polytechnics, Ministry of Health Surakarta


Background: Diabetes mellitus (DM) type 2 is the most common type of diabetes caused by insulin resistance and relative deficiency of insulin secretion. Several studies have shown inconsistent results regarding the effect of Zingiber officinale powder in patients with type 2 DM. As a result of these inconsistencies, researchers are compelled to prove the effect of Zingiber officinale powder on fasting blood sugar (GDP) and HbA1c levels in type 2 DM patients through a meta-analysis study.

Subject and Method: This study is a meta-analysis of a number of randomized controlled trials. The articles were obtained from the PubMed, Science Direct, Springerlink and Google Scholar databases published in 2012-2022. The search articles were carried out by considering the feasibility of the criteria determined using the PICO model. Population: type 2 DM patients, Intervention: Zingiber officinale rhizome powder, Comparison: placebo, Outcome: GDP and HbA1c levels. The keywords used are “Zingiber officinale” OR “Zingiber” OR “Z. officinale” OR “Ginger” AND “Fasting blood glucose” AND “HbA1c” OR “A1c” OR “Glicemic” OR “Glucose” OR “Diabetes Mellitus” OR “type 2 diabetes mellitus” AND “Randomized Controlled Trial”. Article selection with PRISMA flow diagram. Analysis of articles using the Revman 5.3 application.

Results: A total of 11 articles were reviewed in this study. Analysis of 11 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce GDP levels in type 2 DM patients (Standardized Mean Difference (SMD)= -0.79; 95% CI= -1.32 to -0.26; p= 0.004). Analysis of 10 articles showed that administration of Zingiber officinale rhizome powder could significantly reduce HbA1c levels (SMD = -0.38; 95% CI= -0.55 to -0.22; p<0.001).

Conclusion: Zingiber officinale rhizome powder can significantly reduce GDP and HbA1c levels in type 2 DM patients.

Keywords: Zingiber officinale, diabetes mellitus tipe 2, GDP, HbA1c

Correspondence: Fajar Novianto. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir.Sutami No.36, Surakarta, Central Java, Indonesia. Email: dr.fajarnovianto@gmail.com.

Indonesian Journal of Medicine (2022), 07(01): 39-50


Akash MSH, Rehman K, Tariq M, Chen S (2015). Zingiber officinale and type 2 diabetes mellitus: Evidence from experimental studies. Crit Rev Eukar Gene. 25(2): 91–112. Doi: 10.1615/CritRevEukaryotGeneExpr.2015013358.

ADA. (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care. 33 (SUPPL. 1). Doi: 10.2337/dc10S062.

Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A, Djalali M (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 65(4): 515–520. Doi: 10.3109/09637486.2014.880671

Arzati MM, Honarvar NM, Saedisomeolia A, Anvari S, Effatpanah M, Arzati RM, Yekaninejad MS, et al. (2017). The effects of ginger on fasting blood sugar, hemoglobin A1c, and lipid profiles in patients with type 2 diabetes. Int J Endocrinol Metab. 15(4): 1–6. Doi: 10.5812/ijem.57927

Carvalho GCN, LiraNeto JCG, Araújo MFM, de Freitas RWJF, de Zanetti ML, Damasceno MMC (2020). The effectiveness of ginger in reducing metabolic levels in people with diabetes: a randomized clinical trial. Rev Lat Am Enfermagem. 28: e3369. Doi: 10.1590/15188345.3870.3369

Ebrahimzadeh A, Mirghazanfari SM, Hazrati E, Hadi S, Milajerdi A (2022). The effect of ginger supplementation on metabolic profiles in patients with type 2 diabetes mellitus: A systematic review and metaanalysis of randomized controlled trials. Complement Ther Med. 65 (May): 102802. Doi: 10.1016/J.CTIM.2022.102802

El Gayar MH, Aboromia MMM, Ibrahim NA, Abdel Hafiz MH (2019). Effects of ginger powder supplementation on glycemic status and lipid profile in newly diagnosed obese patients with type 2 diabetes mellitus. Obes Med. 14(9): 100094. Doi: 10.1016/j.obmed.2019.100094.

Elsaadany MA, AlTwejry HM, Zabran RA, AlShuraim SA, AlShaia WA, Abuzaid OI, AlBaker WI (2021). Antihyperglycemic Effect of Fenugreek and Ginger in Patients with Type 2 Diabetes: A DoubleBlind, Placebocontrolled Study. Curr Nutr Food Sci. 18(2): 231–237. Doi: 10.2174/1573401317666210706121806.

Gholinezhad H, Bazyar H, Rashidi H, Salehi P, Haghighizadeh MH, Javid AZ (2020). Using ginger supplement in adjunct with nonsurgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2 diabetes mellitus and chronic periodontitis: A doubleblind, placebocontrolled trial. J Herb Med. 20: 100315. Doi: 10.1016/j.hermed.2019.100315.

Huang FY, Deng T, Meng LX, Ma XL (2019). Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and metaanalysis. Medicine. 98(13): e15054. Doi: 10.1097/MD.0000000000015054.

IDF (2021). IDF Diabetes Atlas 10th edition. https://diabetesatlas.org/idfawp/resourcefiles/2021/07/IDF_Atlas_10th_Edition_2021.pdf. Accessed in February 2, 2022.

Kemenkes RI (2019). Riskesdas (Riset Kesehatan Dasar) 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan RI.

Kemenkes RI (2020). Tetap produktif, cegah dan atasi diabetes mellitus (Stay Productive, Prevent And Overcome Diabetes Mellitus). Jakarta: Pusat Data dan Informasi Kementrian Kesehatan RI.

Khandouzi N, Shidfar F, Rajab A, Rahideh T, Hosseini P, Taheri MM (2015). The Effects of Ginger on Fasting Blood Sugar, Hemoglobin A1c, Apolipoprotein B, Apolipoprotein AI and Malondialdehyde in Type 2 Diabetic Patients. Iran J Pharm Res. 14(1): 131. Doi: 10.22037/ijpr.2015.1632.

Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE (2013). Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 64(6): 682–686. Doi: 10.3109/09637486.2013.775223.

MozaffariKhosravi H, Talaei B, Jalali BA, Najarzadeh A, Mozayan MR (2014). The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, doubleblind, placebocontrolled trial. Complement Ther Med. 22(1): 9–16. Doi: 10.1016/j.ctim.2013.12.017

Murti B. (2018). Prinsip dan Metode Riset Epidemiologi. Colomadu: Bintang Fajar Offsite.

PERKENI (2019). Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia (Management and Prevention of Type 2 Diabetes Mellitus in Indonesia). In Perkumpulan Endokrinologi Indonesia. PB PERKENI. https://pbperkeni.or.id/wpcontent/uploads/2021/06/PedomanPengelolaanDMTipe2DewasadiIndonesiaeBookPDF.pdf. Accessed in February 2, 2022.

Petersmann A, MüllerWieland D, Müller UA, Landgraf R, Nauck M, Freckmann G, Heinemann L, et al. (2019). Definition, Classification and Diagnosis of Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 127(S01): S1–S7. Doi: 10.1055/a10189078.

Rahimlou M, Yari Z, Rayyani E, Keshavarz SA, Hosseini S, Morshedzadeh N, Hekmatdoost A (2019). Effects of ginger supplementation on anthropometric, glycemic and metabolic parameters in subjects with metabolic syndrome: A randomized, doubleblind, placebocontrolled

study. J Diabetes Metab Disord. 18(1): 119–125. Doi: 10.1007/s4020001900397z.

Shidfar F, Rajab A, Rahideh T, Khandouzi N, Hosseini S, Shidfar S (2015). The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 12(2): 165–170. Doi: 10.1515/jcim20140021.

WHO (2021). Diabetes. World Health Organization. https://www.who.int/newsroom/factsheets/detail/diabetes. Accessed in December, 2021.