The Effectiveness of Ethanol Extract Chayote (Sechium Edule (Jacq.) Swartz) Fraction and Juice on Pancreatic β-Cell Diameter of Male White Rats Wistar Strain with Type 2 Diabetes Mellitus


  • Sanggam Bangun Hutagalung Department of Anatomical Pathology, Faculty of Medicine, Universitas Methodist Indonesia, Medan
  • Jekson Martiar Siahaan Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan
  • Hendrika Andriana Silitonga Department of Histology, Faculty of Medicine, Universitas Methodist Indonesia, Medan


Background: Diabetes Mellitus is character­rized by metabolic disturbances due to pro­longed hyperglycemia, causing oxidative stress, which destroys pancreatic β cells. Adjuvant therapy that has antihyperglycemic effective­ness and is required to improve the diameter of pancreatic beta cells, one of which comes from Sechium edule (Jacq.) Swartz has poten­tial as an antihyperglycemic, antioxidant, anti­apop­tosis, cardioprotective, insulin resistance. This study aimed to examine the effectiveness of ethanol extract, Chayote (Sechium Edule (Jacq.) Swartz) fraction, and juice on the pancreatic β-cell diameter of white male rats Wistar strain with type 2 diabetes mellitus.

Subjects and Method: This was a rando­mized controlled trial. Sample was Rattus novergius sp. 54 tails. The dependent variable was the diameter of the pancreatic β cells. The independent variables were ethanol extract, Sechium edule (Jacq.) Swartz fraction and juice, at a dose of 50 mg/kg BW, 100 mg/ kg BW, 150 mg/kg BW. The data were analyzed by the ANOVA test.

Results: The group of mice induced by Strep­tozotocin 50 mg/kg BW + nicotinamide (120 mg/ kg BW) + HFD and obtained ethanol extract of chayote fruit 150 mg/ kg BW, orally, had the highest pancreatic β cell diameter com­pared to the other groups (Mean= 284.03; SD= 5.15).

Conclusion: Sechium edule (Jacq.) Swartz has potential as an anti-apoptosis that can inhibit pancreatic β cell damage

Keywords: pancreatic β cells, anti-apoptosis

Correspondence: Sanggam Bangun Hutagalung. Department of Anatomical Pathology, Faculty of Medicine, Universitas Methodist Indonesia, Medan. Jl. Setia Budi Pasar II Tj. Sari, Medan 20132, North Sumatera. Email: sanggam1973@­

Indonesian Journal of Medicine (2021), 06(03): 239-245­2021.06.03.01



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