Comparison Neutrophil to Lymphocyte Count Ratio with C-Reactive Protein as a Predictor for Neonatal Sepsis


  • Irfan Dzakir Nugroho Masters Program in Family Medicine, Universitas Sebelas Maret
  • Dwi Hidayah Department of Pediatrics, Dr. Moewardi Hospital, Surakarta
  • Harsono Salimo Department of Pediatrics, Dr. Moewardi Hospital, Surakarta


Background: Accurate early detection of bacteriemia plays an important role in the treatment and prognosis of infected neonates, but is constrained by the limitations of spe­cific sepsis markers for detecting bacteriemia. NLCR or neutrophil to lymphocyte count ratio in adult population shows a more sen­sitive parameter in predicting infection and has the advantage of being economical and widely available. The role of NLCR in the neonatal population has not been widely studied. The purpose of this study was to analyze NLCR versus CRP as a predictor of neonatal sepsis.

Subjects and Method: This study take ana­lytic observatinal with diagnostic test approach to subject with sepsis risk factor and neonatal sepsis at dr. Moewardi hospital from April until May 2017. Characteristics data as gestational age, gender, birth weight, IT ratio, leucocyte count, neutrophil and lym­phocyte count, NLCR, CRP and blood culture. Data presented descriptively and statistical analysis was performed.

Results: No significant correlation between subject’s characteristics and neonatal sepsis. NLCR with cutoff point for 2.22 has sensi­ti­vity, specificity, positive and negative pre­dictive value for 87.5%, 75%, 70% and 90%, respec­ti­vely. CRP with cutoff point for 0.25 has sensi­tivity, specificity, positive and nega­tive predic­tive value for 83.3%, 55.6%, 55.6% and 83.3% respectively. While IT-rasio has sensitivity, spe­cificity, positive and negative predictive value for 29.2%, 91.7%, 70% and 66%, respectively.

Conclusion: NLCR has a satisfactory pre­dictive value for neonatal sepsis that widely available and economic predictor alternative with cutoff point for 2.22.

Keywords: NLCR, CRP, predictor, neonatal sepsis

Correspondence: Irfan Dzakir Nugroho. Masters Program in Family Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java.

Indonesian Journal of Medicine (2021), 06(01): 112-118



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