Giant Cell Tumor of the Phalanx of Finger: Case Reports

Authors

  • Pamudji Utomo Department of Orthopaedic and Traumatology, Prof. Dr. R. Soeharso Orthopaedics Hospital/Faculty of Medicine, Universitas Sebelas Maret
  • Mujaddid Idulhaq Department of Orthopaedic and Traumatology, Prof. Dr. R. Soeharso Orthopaedics Hospital/Faculty of Medicine, Universitas Sebelas Maret
  • Ambar Mudigdo Department of Pathology and Anatomy, Faculty of Medicine, Universitas Sebelas Maret
  • Okkie Mharga Sentana Department of Orthopaedic and Traumatology, Prof. Dr. R. Soeharso Orthopaedics Hospital/Faculty of Medicine, Universitas Sebelas Maret

Abstract

Background: Giant cell tumor (GCT) of bone arising from aphalanx of finger is extremely rare. Although, the occurrence of GCT in the hands is a rare, it has been reported that GCT of the small bones (small-bone GCT) carries a higher risk of local recurrence and metastasis than conventional GCT.

Subjects and Method: We report two cases of GCT arising from a phalanx of a hand finger. First patient was treated with wide excision of the tumor and fusion with fibular bone graft with the help of a K-wire. Second patient was treated by excision of tumour (Curretage) with allograft bonegraft for bone defect.

Results: At their most recent follow-ups (4 months, respectively), both were recurrence free and had returned to their previous occupational and recreational activities.

Conclusion: The effectiveness of these methods in the treatment and prevention of recurrence is still under discussion and there is no gold standard for treating GCT.

Keywords: GCT, phalanx of finger, excision, illiac crest bonegraft, allograft

Correspondence: Pamudji Utomo. Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta, Central Java. Email: utomodr@yahoo.com.

Indonesian Journal of Medicine (2019), 4(1): 65-74
https://doi.org/10.26911/theijmed.2019.04.01.11

References

Algawahmed H, Turcotte R, Farrokhyar F, Ghert M (2010). High-speed burring with and without the use of surgical adjuvants in the intralesional management of giant cell tumor of bone: a systematic review and meta-analysis. Sarcoma. http://dx.doi.org/10.1155/-2010/586090. Article ID 586090. doi: 10.1155/2010/586090  Crossref  PubMed  Google Scholar 

Athanasian EA, Wold LE, Amadio PC (1997). Giant cell tumors of the bones of the hand. J Hand Surg. 22A: 91-98. doi: 10.1016/S0363-5023(05)80187-X  Crossref  PubMed  Google Scholar 

Averill RM, Smith RJ, Campbell CJ (1980). Giant-cell tumors of the bones of the hand. J Hand Surg. 5A: 39-50. doi: 10.1016/S0363-5023(80)80042-6  Crossref  PubMed  Google Scholar 

Balke M, Campanacci L, Gebert C, et al. (2010). Bisphosphonate treatment of aggressive primary, recurrent and metastatic giant cell tumour of bone. BMC Cancer. 2010(10): 462-470. doi: 10.1186/1471-2407-10-462  Crossref  PubMed  Google Scholar 

Becker WT, Dohle J, Bernd L, et al. (2008). Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Jt Surg Am. 90: 1060e1067. doi: 10.2106/JBJS.D.02771  Crossref  PubMed  Google Scholar 

Bloodgood JC (1919). Bone tumours central (medullary) giant cell tumor (sarcoma) of lower end of ulna, with evidence that completedestruction of the bony shell or perforation of the bony shell is not asign of increased malignancy. Ann Surg. 69: 345-59. doi: 10.1097/00000658-191904000-00001  Crossref  PubMed  Google Scholar 

Campanacci M, Baldini N, Boriani S, Suda-nese A (1987). Giant-cell tumor of bone. J Bone Joint Surg Am. 69:106-14. Crossref  PubMed  Google Scholar 

Coley BL, Higisibotham NL, Koguse T (1958). Giant cell tumor of bone. Am Jsurg. 96:479-91. doi: 10.1016/0002-9610(58)90963-2  Crossref  PubMed  Google Scholar 

Dahl in DC (1985). Giant cell tumor of bone: high lights of 407 cases. AJR Am J Roentgenol. 144(5): 955-60.. doi: 10.2214/ajr.144.5.955  Crossref  PubMed  Google Scholar 

Dahlin DC (1996). Dahlins Bone Tumours: General Aspects and Data of11,087 Cases. 5th ed. Philadelphia: Lippincott-Raven. Google Scholar 

Dasan T, Vijay K, Satish C, Nagraj B, Nataraj B (2012). Comprehensive case report of a giant cell tumor involving the proximal phalanx of the left great toe managed with fibular grafting. The Internet Journal of Radiology. 14(1): 1-7. Website

Dickson BC, Li SQ, Wunder JS (2008). Giant cell tumor of bone express p63. Mod Pathol. 21: 369-375. doi: 10.1038/modpathol.2008.29  Crossref  PubMed  Google Scholar 

Errani C, Ruggieri P, Asenzio MA, et al. (2010). Giant cell tumor of the extremity: a review of 349 cases from a single institution. Cancer Treat Rev. 36: 1e7. doi: 10.1016/j.ctrv.2009.09.002  Crossref  PubMed  Google Scholar 

Fnini S, Labsaili N, Messoudi A, Largab A (2008). Giant cell tumor of the thumb proximal phalanx: resection-iliac graft and double arthrodesis. Chir Main. 27 (1): 54-57. doi: 10.1016/j.main.2007.10.007  Crossref  PubMed  Google Scholar 

Frassica FJ, Sanjay BK, Unni KK, et al. (1993). Benign giant cell tumor. Orthopedics. 16(10): 1179-83. PubMed  Google Scholar 

Goldenberg RR, Campbell CJ, Bonfiglio M (1970). Giant-cell tumor of bone.An analysis of two hundred and eighteen cases. J Bone Joint Surg Am. 52: 619-64. PubMed  Google Scholar 

Goldenberg RR, Campbell CJ, Boniglio M, et al. (1970). Giant-cell tumor of bone. An analysis of two hundred and eight-een cases. J Bone Joint Surg Am. 52(4): 619-64. PubMed  Google Scholar 

Jackson K, Key CH, Fontaine M, Pope R (2012). Recurrence of a giant cell tumor of the hand after 42 Years: case report. J Hand Surg. 37(4): 783-786. doi: 10.1016/j.jhsa.2011.12.005  Crossref  PubMed  Google Scholar 

Jones KB, DeYoung BR, Morcuende JA, Buckwalter JA (2006). Ethanol as a local adjuvant for giant cell tumor of bone. Iowa Orthop J. 26: 69-76. PubMed  Google Scholar 

Lopez‑Barea F, Rodriguez‑Peralto JL, Garcia‑Giron J, Guemes‑Gordo F (1992). Benign metastasizing giant‑cell tumor of the hand. Report of a case and review of the literature. Clin Orthop Relat Res. 274:270‑274. PubMed  Google Scholar 

Malawer M, Wittig J, Bickles J (2012). Operative Techniques in Orthopaedic Surgical Oncology. Lippincot &: Wilkins, a Wolters Kluwer. Google Scholar 

Malawer MM, Bickels J, Meller I, Buch RG, Henshaw RM, Kollender Y (1999). Cryosurgery in the treatment of giant cell tumor. A long-term follow-up study. Clin Orthop Relat Res. 359:176-188. doi: 10.1097/00003086-199902000-00019  Crossref  PubMed  Google Scholar 

Marcove RC, Weis LD, Vaghaiwalla MR, Pearson R, Huvos AG. Cryosurgery in the treatment of giant cell tumors of bone. A report of 52 consecutive cases. Cancer. 1978(41) :957-969. PubMed  Google Scholar 

Minhas M, Mehboob G, Ansari I (2010). Giant cell tumours in hand bones. Journal of the College of Physicians and Surgeons Pakistan. 20(7): 460-463. PubMed  Google Scholar 

Moon JC, Kim SR, Chung MJ, Lee YC (2012). Multiple pulmonary metastases from giant cell tumor of a hand. Am J Med Sci. 343(2):171-3. doi: 10.1097/MAJ.0b013e31823483e1  Crossref  PubMed  Google Scholar 

Nouri H, Meherzi MH, Ouertatani M, et al. (2011). Use of calcitonin in giant cell tumors of bone. Orthop Traumatol Surg Res. 97: 520-526. Google Scholar 

Patel MR, Desai SS, Gordon SL, Nimberg GA, Sclafani SJ, Vigorita VJ, et al. (1987). Management of skeletal giant cell tumors of the phalanges of theand. J Hand Surg Am. 12:70-7. doi: 10.1016/S0363-5023(87)80163-6  Crossref  PubMed  Google Scholar 

Daftar Pustaka dengan DOI. Reichert P, Kowalski P, Gosk J (2017). The giant cell tumour of the proximal phalanx of the thumb treated by a 2-stage operation. Acta Orthopaedica et Traumatologica Turcica. 51: 425-428. doi: 10.1016/j.aott.2017.03.015  Crossref  PubMed  Google Scholar 

Saikia KC, Bhuyan SK, Goswami S, Bora A (2009). Rare site giant cell tumors: Report of two cases on phalanges of the finger and review of literature.J Orthop Traumatol. 10: 193-7. (Giant cell tumour of a proximal phalanx treated with enbloc resection, buddhika). doi: 10.1007/s10195-009-0067-1  Crossref  PubMed  Google Scholar 

Scully SP, Mott MP, Temple HT, O'Keefe RJ, O'Donnell RJ, Mankin HJ (1994). Late recurrence of giant-cell tumor of bone: a report of four cases. J Bone Jt Surg. 76A: 1231-1233. doi: 10.2106/00004623-199408000-00013  Crossref  PubMed  Google Scholar 

Thomas S, Henshaw R, Skubitz K, et al. (2010). Denosumab in patients with giant cell tumour of bone:an open-label, phase 2 study. Oncol Lancet. 11: 275e280. doi: 10.1016/S1470-2045(10)70010-3  Crossref  PubMed  Google Scholar 

Trieb K, Bitzan P, Lang S, Dominkus M, Kotz R (2001). Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy. Eur J Surg Oncol. 27 (2): 200-202. doi: 10.1053/ejso.2000.1086  Crossref  PubMed  Google Scholar 

Williams J, Hodari A, Janevski P, Siddiqui A (2010). Recurrence of giant cell tumors in the hand: a prospective study. J Hand Surg. 35(3): 451-456. doi: 10.1016/j.jhsa.2009.12.004  Crossref  PubMed  Google Scholar 

Wittig J, Simpson B, Bickels J, Kellar-Graney K, Malawer M (2001). Giant Cell Tumor of the Hand: Superior Results With Curettage, Cryosurgery, and Cementation. The Journal of Hand Surgery. 26(3): 546-554. doi: 10.1053/jhsu.2001.22525  Crossref  PubMed  Google Scholar 

Yanagisawa M, Okada K, Tajino T, Torigoe T, Kawai A, Nishida J (2011). A clinicopathological study of giant cell tumor of small bones. Ups J Med Sci. 116(4) : 265-268. doi: 10.3109/03009734.2011.596290  Crossref  PubMed  Google Scholar 

Yasuda T, Kanamori M, Ishizawa S, Nogami S, Hori T, Suzuki K, et al. (2008). Multicentric diffuse‑type giant cell tumor of the hand. Mod Rheumatol. 18: 67‑71. doi: 10.1007/s10165-007-0005-0  Crossref  PubMed  Google Scholar 

Downloads

Published

2019-01-10

Issue

Section

Articles