The Difference of Bovine Bone Graft and Iliac Crest Bone Graft Effect on Closure of Bone Defect in Alveolar Bone Graft in Dr. Moewardi Hospital and Panti Waluyo Hospitals, Surakarta
Abstract
Background: Cleft lip and palate (CLP) is a case of craniofacial congenital abnormalities that are often found by plastic surgeons. Successful management requires good surgical techniques, deep understanding of anatomical abnormalities and three-dimensional aspects of facial aesthetics. The Alveolar bone graft (ABG) aims to unite and stabilize Maxilla before definitive orthodontic action and restoration of dental care. The use of bone grafts in the surgical field is often done, aimed at maximizing the process of bone healing. Autogenous bone graft is the gold standard bone graft material because it contains all the properties needed in bone formation. The iliac crest bone graft (ICBG) is the most commonly used donor. Bromine bone graft (BBG) is increasingly being used as a substitute for autogenous bone graft. The purpose of this study was to determine the differences in the effect of the percentage of defect closure between CNG and ICBG on the closure of defects in ABG.
Subjects and Method: The retrospective cohort study was conducted at Dr. Moewardi and Panti Waluyo Hospitals, Surakarta, Central Java, Indonesia, from February to April 2018. The dependent variable was bone defect closure. The independent variables were bovine bone and iliac crest bone grafts. The data were analyzed by Mann-Whitney.
Results: Most patients after ABG surgery have a percentage of bone defect closure of 75-100% with bone resorption of 0-25% and include type I Bergland scale, where ICBG (66.7%) tends to be better than BBG (55.6%), but statistically not significant (p value = 0.678).
Conclusion: There is no difference in the effect of the percentage of defect closure between CNG and ICBG on the closure of defects in ABG. ICBG tends to give a better percentage of defect closure than CNG, but it is not statistically significant.
Keywords: Cleft lip and palate (CLP), Alveolar bone graft, bovine bone graft, Iliac crest bone graft, closure of bone defects.
Correspondence: Ruzbih Bahtiar. Department of Surgery, Dr. Moewardi Hospital, Surakarta/Faculty of Medicine, Universitas Sebelas Maret.
Indonesian Journal of Medicine (2018), 3(3): 151-161
https://doi.org/10.26911/theijmed.2018.03.03.05
References
Aly LAA, Hammouda N (2016). Secondary closure of Alveolar cleft with resorbable collagen membrane and a combination of intraoral autogenous bone graft and deproteinized anorganic bovine bone. Ann Maxillofac Surg. 6(2): 165–171.
Bauer TW, Muschler GF (2000). Bone graft materials. An overview of the basic science. Clininical Orthop Relat Res. 371, 10-27.
Buckwalter JA, Einhorn TA, Marsh JL, Gulotta L, Ranawat A, Lane J (2006). Bone and Joint Healing. In RH. Bucholz, Rockwood And Green's Fractures In Adults. 7th Edition. 298 – 303). USA: Lippincott Williams & Wilkins.
Conway J (2010). Autograft and nonunions: morbidity with intramedullary bone graft versus iliac crest bone graft. Orthopaedy Clinic North America. 41(1): 75–84.
Da Silva FOG, Ozawa TO, Bachega C, Bachega MA (2013). Reconstruction of alveolar cleft with allogenous bone graft: Clinical considerations. Dental Press Journal Of Orthodontic. 18(6): 138-147.
De Long WG, Einhorn TA, Koval K (2007). Bone grafts and bone graft substitutes in orthopaedic trauma surgery: A critical analysis. The Journal of Bone and Joint Surgery. 89(3): 649-658.
Dimitriou R, Jones E, McGonagle D, Giannoudis PV (2011). Bone Regeneration: Current Concepts and Future Directions. BMC Medicine. 9(66): 1-10.
Dimitrioua R, Mataliotakis GI, Angoules AG, Kanakaris NK, Giannoudis PV (2011). Complications following autologous bone graft harvesting from the iliac crest and using the RIA: A systematic review. International Journal Care Injured, 3-15.
Elsalanty ME, Genecov DG (2009). Bone grafts in craniofacial surgery. Craniomaxillofacial Trauma & Reconstruction. 2(3): 125-134.
Ferdiansyah J, Rushadi D, Rantam FA (2011). Regeneration of massive bone defect with bovine hydroxyapatite as scaffold of mesenchymal stem cells. JBP. 13(3): 179–195.
Goudy S, Lott D, Burtom R, Wheeler, Canadi J (2009). Secondary alveolar bone grafting: Outcomes, revisions, and new applications. Cleft Palate–Craniofacial Journal. 46(6): 610-612.
Greenwald AS, Boden SD, Goldberg VM, Yaszemski M, Heim CS (2006). Bonegraft substitutes: Facts, fictions, and applications. The Journal of Bone and Joint Surgery, 83-A(2): 98-103.
Holmes RE, Bucholz RW, Mooney V (1986). Porous hidroxyapatite as a bonegraft subtitute in metaphyseal defects. The Journal of Bone and Joint Surgery. 68-A(6): 904-11.
Hopper RA, Cutting C, Grayson B (2007). Cleft lip and palate. In H. Charles, Grabb and Smith's Plastic Surgery Sixth Edition. USA: Lippincott Williams & Wilkins.
Hung N (2016, June 28). Basic Knowledge of Bone Grafting. Retrieved from In TechOpen: http://www.intechopen.com/books/bonegrafting/basicknowledgeofbonegrafting.
Kinderlan JD, Nashed RR, Bromige MR (1997). Radiographic assestment of secondary autogenous alveolar bone grafting in cleft lip and palate patients. Cleft palatecraniofacial Journal. 34(3): 195–198.
Marzoeki D, Jailani M, Perdanakusama DS (2002). Tehnik pembedahan celah bibir dan langit langit. Cetakan Pertama . Jakarta: CV. Sagung Seto.
Myeroff C, Archdeacon M (2011). Autogenous bone graft: donor sites and techniques. Journal Bone Joint Surgery America. 93: 227-36.
Nascimento C, Issa JPM, Oliveira RR, Iyomasa MM, Siéssere S, Regalo SCH (2007). Biomaterials applied to the bone healing process. Int. J. Morphol. 25(4): 839-846.
Oberoi S, Chigurupati R, Gill P, Hoffman WY, Vargervik K (2009). Volumetric assessment of secondary alveolar bone grafting using cone beam computed tomography. The Cleft Palate - Craniofacial Journal. 46(5): 503-511.
Peamkaroonrath C, Godfrey K, Chatrchai-wiwatana S (2011). New clinical method for alveolar bone graft evaluation in cleft patients: A Pilot Study. Cleft Palate–Craniofacial Journal. 48(3): 286-292.
Steinberg B, Chiego DJ, Huizinga PJ (1999). Effect of human bone morphogenetic protein 2 implant on tooth eruption in an experimental design. Journal Craniofacacial Surgery. 10(4): 338-341.
Vogens E, Jones NF, Huang JI (2005). Healing of citical sized defect in the rat femur with use of a vasvularized periosteal flap, a biodegradable matrix, and bone morphogeneric poteins. Journal Bone Joint Surgery. 87(6): 1323-1331.
Vuletic M, Knezevic P, Jokic D, Rebic J, Zabarovic D, Macan D (2014). Alveolar bone grafting in cleft patients: from bone defect to dental implants. Acta Stomatologica Croatia. 48(4): 250-257.
Wang Y (2003). Collagen–hydroxyapatite microspheres as carriers for bone morphogenics protein–4. International Society for Artificial Organ. 27(2): 162-8.
Wiedel AP, Svensson H, Schoenmeyr B, Becker M (2015). An analysis of com-plications in secondary bone grafting in patients with unilateral complete cleft lip and palate. Journal of Plastic Surgery and Hand Surgery, Early Online: 1-5.
