Effect of Cardiac Rehabilitation on NT-Pro BNP, METS, and Quality of Life, in Patients with Coronary Artery Disease after Undergoing Percutaneous Coronary Intervention
Abstract
Background: Percutaneous coronary intervention (PCI) is one of the most effective therapies in patients with coronary artery disease (CAD) after the attack. Cardiac rehabilitation (CR) makes an important contribution to secondary prevention of cardiac events. The World Health Organization defines CR as the sum of activities required to influence favorably the underlying cause of the disease, as well as to ensure the best possible physical, mental and social conditions, so that they may, by their own efforts, preserve or resume when lost as normal a place as possible in the life of the community. This study aimed to estimate the effects of CR on NT-proBNP and METs among patients with CAD after PCI.
Subjects and Method: This was a cohort study carried out at Dr. Moewardi Hospital, Surakarta, Central Java, from November to February 2018. A sample of 18 patients with CAD after PCI was selected for this study. The dependent variables were NT-proBNP, METs, and quality of life. The independent variable was CR. The three outcome variables were measured before and after CR. The data before and after CR were compared and tested by t-test.
Results: NT-proBNP level in CAD patients after PCI (Mean= 97.17 ng/ml) was lower than before PCI (Mean= 1,629.4 ng/ml), and it was statistically significant. METS value in CAD patients after PCI (Mean= 8.31 ml/kg) was higher than before PCI (Mean= 6.41 ml/kg), and it was statistically significant. The quality of life also increased significantly.
Conclusion: Cardiac rehabilitation is effective to lower NT-proBNP level, as well as to increase METS value and quality of life of CAD patients.
Keywords: coronary artery disease, cardiac rehabilitation, NT-proBNP, METs, quality of life
Correspondence: Noer Rachma. Department of Physical Medicine and Rehabilitation, Dr. Moewardi Hospital, Surakarta, Central Java.
Indonesian Journal of Medicine (2018), 3(3): 146-150
https://doi.org/10.26911/theijmed.2018.03.03.04
References
AACVPR (2013). Guideline for cardiac rehabilitation and secondary prevention programs. 5th edition. USA: Human Kinetics.
Arthur H, Smith K, Kodis J, McKelvie R (2002). A controlled trial of hospital versus homebased exercise in cardiac patients. Medicine & Science in Sports & Exercise. 34(10): 1544-1550.
Charlote et al. (2005). NTerminal Pro B Type Natriuretic Peptide and Long Term Mortality ins Stable Coronary Heart Disease. N Engl J Med. 352: 666-675.
Dalal H, Evans P, Campbell J, Taylor R, Watt A, Read K, Mourant A, Wingham J, Thompson D, Pereira GD (2007). Home based versus hospital based rehabilitation after myocardial infarction: a randomised trial with preference arms Cornwall Heart Attack Rehabilitation Management Study (CHARMS). International Journal of Cardiology. 119(2): 202-211.
Jolly K, Lip G, Taylor R (2009). The Birmingham rehabilitation uptake maximization study (BRUM): a randomised controlled trial comparing homebased with controlled trial comparing homebased with centre-based cardiac rehabilitation. Heart. 95(1): 36- 42.
Silber S, Albertsson P, Aviles FF et al. (2005). Guidelines for percutaneous coronary interventions. Eur Heart J. 26:804-847.
Spanaus KS and Eckardstein A. Natriuretic peptides in cardiac and renal failure. Pipette Swiss Laboratory Medicine 2007: 6; 6-11
Vancouver Island Health Authority (VIHA). Activity and exercise guide for heart patients. Heart Health Program. 2011 http://www.viha.ca/NR/rdonlyres/5A962352299E4FDA865BF3930E8-61B76/0/activity_guide_after_heart-_attack_angina_stent_angioplasty-_v13.pdf diakses Februari 2018.
