Hepcidin and Feritin Levels in Obese Pregnant Women and Normal Body Weight before Pregnancy

Hadiyatur Rahma, Sarma N Lumbanraja, Zulfikar Lubis


Background:Obesity is associated with a decrease in iron status, possibly it is an increase in hepcidin, an inflammatory protein that reduces iron absorption. Hepcidin is associated with iron homeostasis and inflammation. This study aims to determine differences in levels of hepcidin and ferritin of obesity pregnant women and normal weight before pregnancy.

Subjects and Method: This was an analytic observational study with a case control design. A total of 62 pregnant women was selected by consecutive technique sampling and divided into 2 groups, namely obesity and normal weight before pregnancy. The study was conducted at RSIA BadrulAini Medan and at RSUP H.Adam Malik Medan from September to December 2016. The dependent variable of this study was the weight before pregnancy. The independent variable washepcidin levels examined by ELISA method, ferritin content with Immunochemiluminescent method. The data analysis employed Mann Whitney's different test.

Results: Median of hepcidin level in obese pregnant women before pregnancy was higher than pregnant mother with normal weight of 7.08 ng / mL (2.14 to 78.18). There was no difference in hepcidin level in both groups (p = 0.578). Median ferritin levels in obese pregnant women were higher than the normal weight of 20.57 μg / L (3.66 to 102.25). There was no difference of ferritin levels in both groups (p = 0.598).

Conclusion: This study showed no difference in hepcidin levels and ferritin levels in obese pregnant women and normal weight before pregnancy.

Keywords: Feritin,hepcidin, obesity before pregnancy, normal body weight before pregnancy

Correspondence: Hadiyatur Rahma. . Department of  Pharmacology, Faculty of Medicine, Islam Sumatera Utara University, Medan. Email:

Indonesian Journal of Medicine (2018), 3(1): 234-238

Full Text:



Ahmed SR,Ellah MAA,Mohamed OA, Eid HM (2009). Prepregnancy Obesity and Pregnancy Outcome. International Journal of Health Sciences, Qassim University, 3(2).

Bekri S, Gual P, Anty R (2006). Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology.131:788-796.

Cepeda Lopez AC, Osendarp SJ, Melse Boonstra A, Aeberli I, Gonzalez Salazar F, Feskens E, Villalpando S, Zimmermann MB (2011). Sharply higher rates of iron deficiency in obese Mexican women and children are predicted by obesity related inflammation rather than by differences in dietary iron intake. Am J Clin Nutr.93:975-83.

Chung B, Matak P, McKie AT, Sharp P (2007). Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr.137:236670

Dao MC, Sen S, Iyer C, Klebenov D, Meydani SN (2013).Obesity during pregnancy and fetal iron status: is Hepcidin the link?. J Perinatol. 33:177-81.

Dosch NC, Guslits EF, Weber MB, Murray ES, Ha B, Coe CL, Auger AP (2016). Materal Obesity Affects Inflamatory and Iron Indices in Umbilical Cord Blood. 172:20-28

Greenberg AS, Obin MS (2006). Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 83:S461-S465

Hedengran K, , Nelson, Andersen, Stender, Pal B. Szecsi (2015): Hepcidin levels are low during pregnancy and increase around delivery in women without iron deficiency a prospective cohort study, The Journal of Maternal Fetal & Neonatal Medicine.

Papanikolaou G, Tzilianos M, Christakis JI (2005). Hepcidin in iron overload disorders. Blood, 105:41035.

Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, et al. Maternal obesity and pregnancy outcome: a study of 287,213 pregnan`1 cies in London. Int J Obes Relat Metab Disord 2001;25:1175-82

Schulze KJ, Christian P, Ruczinski I, Ray AL, Nath A, Wu LSF, Semba RD (2008). Hepcidin and iron status among pregnant woman in Bangladesh. Journal of Clinical Nutrition, 17 (13): 451-456.

Simavli S, Derbent AU, Keskin EA, Gumus II, Uysal S, Turhan N (2015). Do the first, second and third trimester maternal serum hepcidin concentration clarify obstetric complications?. J Matern Fetal Neonatal Med, 28(7).

Tussing Humphreys L, Pini M, Ponemone V, Braunschweig C, Fantuzzi G (2011). Suppressed cytokine production in whole blood cultures may be related to iron status and hepcidin and is partially corrected following weight reduction in morbidly obese premenopausal women. Cytokine.53:201-6.

Valdes L, Campoy C, Hayes H, Florido J, Rusanova I, Miranda MT, McArdle HJ (2015). The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. International Journal of obesity. Doi: 10.1038/ijo.215.3.

Weiss G, Goodnough LT (2005). Anemia of chronic disease. N Eng J Med, 352: 1011-23.


  • There are currently no refbacks.