User

Serum Ferritin as a Predictor of Shock in Children with Dengue Infection

Putri Evalda, Bambang Soebagyo, Muhammad Riza

Abstract

Background: Dengue shock syndrome causes high morbidity and mortality among children worldwide. Several laboratory monitoring can be used to evaluate the progressivity of dengue virus infection. This study aimed to analyze ferritin serum as a predictor of shock in children with dengue infection, and to determine the cut off point that can be used to diagnose dengue shock.

Subjects and Method: This was a cross sectional study conducted at pediatric ward, Dr. Moewardi hospital Surakarta Dr. Soetrasno hospital Rembang, Central Java. Study population was children aged less than 18 years old with dengue infection. Study subjects were selected by consecutive sampling. Tha dependent variable was dengue shock. The independent variable was serum ferritin concentration. Mann Whitney test was used to compare mean ferritin concentration between children with and without dengue shock. Cut off point of serum ferritin concentration was determined by ROC curve.

Results: Mean serum ferritin concentration in children with dengue shock (mean= 3628.8; SD= 1582.4) was higher than in children without dengue shock (mean= 717.8; SD= 695.8), with p<0.001. Therefore, there was a statistically significant asssociation between serum ferritin concentration and dengue shock .  The cut off point of serum ferritin concentration that could be used to show dengue shock with high sensitivity (0.92) and specificity (0.97) was 2304.5.

Conclusion: High serum ferritin concentration is a predictor of dengue shock.

Keywords: ferritin, dengue shock syndrome, children

Correspondence: Putri Evalda. Dr. Moewardi Hospital, Jl. Kolonel Sutarto No.132 Jebres, Surakarta, Central Java 57126. Email: dr. putri.evalda@gmail.com. Mobile: 081227970440

Indonesian Journal of Medicine (2017), 2(3): 154-160
https://doi.org/10.26911/theijmed.2017.02.03.02

Full Text:

PDF

References

Cahyaningrum JMH (2009). Indeks efusi pleura sebagai prediktor sindrom syok dengue pada anak di RSUD Dr. Moewardi Surakarta. Tesis Fakultas Kedokteran UNS. Surakarta

Chaiyaratana W, Chuansumrit A, Atamasirikul K, Tangnararatchakit K (2008). Serum ferritin levels in children with dengue infection. Southeast Asian J Trop Med Public Health. 39:832-6.

Hadinegoro SR, Moedjito I, Chairulfatah A (2014). Pedoman diagnosis dan tatalaksana infeksi virus dengue pada anak. Jakarta: Badan penerbit Ikatan Dokter Anak Indonesia.

Hung NT, Lan NT, Lei HY, Lin YS, Lien LB, Huang KJ, et al (2006). Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. Am J Trop med Hyg. 74:684-91.

Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, et al (1997). Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 176: 313-21.

Phuong CXT, Nhan NT, Kneen R, Thuy PTT, Thien CV, Thuy Nga NT et al (2004). Clinical diagnosis and assessment of severity of confirmed dengue infections in Vietnamese children is the World Health Organization classification system helpful. Am J Trop Med Hyg. 70:172-9.

Pichainarong N, Mongkalangoon N, Kalayanarooj S, Chaveepojnkamjorn W (2006). Relationship between body size and severity of dengue hemorrhagic fever among children aged 0-14 years. Southeast Asian J Trop Med Public Health. 37: 283-8.

Setiati TE, Mairuhu ATA, Koraka P, Supriana M, Mac Gillavry MR, Brandjes DPM, et al (2007). Dengue disease severity in Indonesian children; an children: an evaluation of the World Health Organization classification system. BMC Infect Dis. 7:1-8.

Van de Weg C, Huits R, Pannuti C, Brouns R, van den Berg R, van den Ham H, et al. (2014). Hyperferritinemia in dengue virus infected patients is associated with immune activation and coagulation disturbances. PLOS journal. 8:1-11

Widiyati MMT, Laksanawati ID, Prawirohartono EP (2013). Obesity as a risk factor for dengue shock syndrome in children. Paediatr Indones. 53:187-92.

World Health Organization (2011) Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever. Revised and expanden edition. New Delhi: WHO.

_____ (2009). Dengue guidelines for diagnosis, treatment, prevention and control. New Edition. Geneva: WHO.

_____ (1997). Dengue: guidelines for diagnosis, treatment, prevention and control. New Edition. Geneva: WHO.

Refbacks

  • There are currently no refbacks.