The Correlation between Allergic Diseases and Systemic Lupus Erythematosus

Dewi Pratiwi, Yulyani Wediningsih, Ari Matea, Kirana Pawitra Nareswari, Niken Dyah Aryani


Background: The prevalence of autoimmune diseases and major chronic allergic diseases such as allergic rhinitis, asthma, and atopic dermatitis are increasing in line with the occurrence of climate change. Allergy and systemic lupus erythematosus (SLE) are sometimes being linked since both are immune diseases involving gene-environment interactions. The purpose of this research is to investigate the correlation between allergic diseases and SLE.

Method: This case-control study was performed on 39 SLE subjects from the Tittari Community and 39 non-SLE subjects aged 15-49 years old, from September until October 2021. All of them were females. The independent variable was allergic disease and the dependent variable was SLE. Partici­pants' characteristics and allergy data were collected through answering the online Score for Allergic Rhinitis (SFAR) questionnaire, then the results were processed with bivariate and multivariate analyses.

Results: The correlation between allergic diseases and SLE was significant for atopic dermatitis but not for allergic rhinitis and asthma (p=0.018; p=0.352; p=0.151 respectively). The bivariate analysis revealed that the risk of SLE was 3.17 times higher in atopic dermatitis patients (OR=3.17; 95% CI=1.20-8.39; p=0.018). Furthermore, the multivariate analysis found that subjects with atopic dermatitis had the highest risk of SLE (OR= 3.18; 95% CI= 1.07-9.51; p=0.031).

Conclusion: Among allergic diseases, atopic dermatitis was found to be significantly correlated with SLE, where the risk of SLE was raised as the number of atopic dermatitis increased.

Keywords: systemic lupus erythematosus, allergic diseases, allergic rhinitis, asthma, atopic dermatitis

Correspondence: Dewi Pratiwi. Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Sebelas Maret – Moewardi Hospital, Indonesia. Email: Phone: (0271) 664569.

Indonesian Journal of Medicine (2022), 07(01): 19-27

Full Text:



Chan TC, Hu TH, Chu YH, Hwang JS (2019). Assessing effects of personal behaviors and environmental exposure on asthma episodes: A diarybased approach. BMC Pulm Med. 19(1): 1–11.

Charoenngam N, Ponvilawan B, Rittiphairoj T, Tornsatitkul S, Wattanachayakul P, Rujirachun P, Ungprasert P (2020). Patients with asthma have a higher risk of rheumatoid arthritis: A systematic review and metaanalysis. Semin Arthritis Rheum. 50(5): 968–976.

ConfinoCohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A (2012). Chronic urticaria and autoimmunity: Associations found in a large population study. J Allergy Clin Immunol. 129(5): 1307–1313.

Guo R, Zhou Y, Lu L, Cao L, Cao J (2017). Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease. PLoS One 12(5): e0177774.

Hsiao YP, Tsai JD, Muo CH, Tsai CH, Sung FC, Liao YT, Chang YJ, et al. (2014). Atopic diseases and systemic lupus erythematosus: An epidemiological study of the risks and correlations. Int J Environ Res Public Health. 11(8): 8112–8122.

Khan A, Shah MH, Nauman M, Hakim I, Shahid G, Niaz P, Sethi H, et al. (2017). Clinical manifestations of patients with Systemic Lupus Erythematosus (SLE) in Khyber Pakhtunkhwa. J Pak Med Assoc. 67(8): 1180–1185.

Krishna MT, Subramanian A, Adderley NJ, Zemedikun DT, Gkoutos G V, Nirantharakumar K (2019). Allergic diseases and longterm risk of autoimmune disorders: Longitudinal cohort study and cluster analysis. Eur Respir J. 54(5): 1900476.

Lam SC, Yeung CCY, Chan JHM, Lam DWC, Lam AHY, AnnesiMaesano I, Bousquet J (2017). Adaptation of the score for allergic rhinitis in the Chinese population: Psychometric properties and diagnostic accuracy. Int Arch Allergy Immunol. 173: 213–224.

Lin CH, Hung PH, Hu HY, Chung CJ, Chen TH, Hung KY (2018). Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide populationbased casecontrol study. Pediatr Allergy Immunol. 29(7): 732–739.

MargeryMuir AA, Bundell C, Nelson D, Groth DM, Wetherall JD (2017). Gender balance in patients with systemic lupus erythematosus. Autoimmun. Rev. 16(3): 258–268.

O’Neill S, Morand EF, Hoi A (2017). The Australian lupus registry and biobank: A timely initiative. Med J Aust. 206(5): 194195.e1.

Pan Q, Chen J, Guo L, Lu X, Liao S, Zhao C, Wang S, et al. (2019). Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus. Am J Transl Res. 11(3): 1241–1254.

Ponvilawan B, Charoenngam N, Wongtrakul W, Ungprasert P (2021). Association of atopic dermatitis with an increased risk of systemic lupus erythematosus: A systematic review and metaanalysis. J Postgrad Med. 67(3): 139–145.

Lin FR, Metter EJ, O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L (2016). Hearing Loss and Incident Dementia. Arch Neurol. 68(2): 214–220.

Widuri A, Fakhriani R (2021). Validity and Reliability of The Indonesian Modification of Score for Allergic Rhinitis. 17(1): 16.

Wongtrakul W, Charoenngam N, Ponvilawan B, Ungprasert P (2020). Allergic rhinitis and risk of systemic lupus erythematosus: A systematic review and metaanalysis. Int J Rheum Dis. 23(11): 1460–1467.

Ziska LH (2020). An overview of rising CO2 and climatic change on aeroallergens and allergic diseases. Allergy Asthma Immunol Res. 12(5): 771–782.


  • There are currently no refbacks.