Meta Analysis the Effect of Physical Activity on Survival Life in Breast Cancer Patients

Enge Surabina Ketaren, Bhisma Murti, Vitri Widyaningsih


Background: Physical activity has a positive role in breast cancer risk. Physical activity inten­sity is often expressed as metabolic equi­valents (METs) and the analytic guidelines for international physical activity question­naires define low activity as 4 METs and high activity as 8 METs. This study aims to estimate the effect of physical activity on the survival of breast cancer survivors based on a number of previous similar studies.

Subjects and Method: This study is a syste­matic review and meta-analysis study. The arti­cles used in this study were obtained from seve­ral databases including PubMed, Science Direct, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The population in the study were breast cancer survivors with an inter­vention in the form of high physical activity. Comparison, namely low physical activity, and an outcome in the form of survival. Keywords for searching articles are as follows: "physical activity" AND "breast cancer survivors" AND "lifesustainability" OR "survival" AND "breast cancer" AND "adjusted hazard ratio" AND "cohort". The articles included in this study are full text articles with a cohort study design. Articles were collected using PRISMA flow dia­grams. Articles were analyzed using the Review Manager 5.3 application.

Results: There were 8 articles originating from Denmark, Norway, Canada, Germany and the United States. The results of the meta-ana­lysis showed that physical activity was statisti­cally significant in increasing the survival of breast cancer survivors (HR= 0.74 95% CI= 0.63 to 0.87; p= 0.0003) and I² = 0%.

Conclusion: High physical activity increases the survival of breast cancer survivors.

Keywords: High physical activity, survival, breast cancer survivors

Correspondence: Enge Surabina Ketaren. Masters Progam in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: Mobile: 087­838583646.

Indonesian Journal of Medicine (2021), 06(01): 32-41


Full Text:



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