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Meta Analysis the Effect of Physical Activity on Survival Life in Breast Cancer Patients

Enge Surabina Ketaren, Bhisma Murti, Vitri Widyaningsih

Abstract

Background: Physical activity has a positive role in breast cancer risk. Physical activity inten­sity is often expressed as metabolic equi­valents (METs) and the analytic guidelines for international physical activity question­naires define low activity as 4 METs and high activity as 8 METs. This study aims to estimate the effect of physical activity on the survival of breast cancer survivors based on a number of previous similar studies.

Subjects and Method: This study is a syste­matic review and meta-analysis study. The arti­cles used in this study were obtained from seve­ral databases including PubMed, Science Direct, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The population in the study were breast cancer survivors with an inter­vention in the form of high physical activity. Comparison, namely low physical activity, and an outcome in the form of survival. Keywords for searching articles are as follows: "physical activity" AND "breast cancer survivors" AND "lifesustainability" OR "survival" AND "breast cancer" AND "adjusted hazard ratio" AND "cohort". The articles included in this study are full text articles with a cohort study design. Articles were collected using PRISMA flow dia­grams. Articles were analyzed using the Review Manager 5.3 application.

Results: There were 8 articles originating from Denmark, Norway, Canada, Germany and the United States. The results of the meta-ana­lysis showed that physical activity was statisti­cally significant in increasing the survival of breast cancer survivors (HR= 0.74 95% CI= 0.63 to 0.87; p= 0.0003) and I² = 0%.

Conclusion: High physical activity increases the survival of breast cancer survivors.

Keywords: High physical activity, survival, breast cancer survivors

Correspondence: Enge Surabina Ketaren. Masters Progam in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ketarenenge3@gmail.com. Mobile: 087­838583646.

Indonesian Journal of Medicine (2021), 06(01): 32-41
https://doi.org/10.26911/theijmed.2021.06.01.04.

 

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References

American Cancer Society (2019). Breast cancer facts & figures 2017-2018. In Handbook of Evidence-Based Radia-tion Oncology. American Cancer So-ciety. https://doi.org/10.1007/978-3-319-62642-0_17.


Ammitzboll G, Søgaard K, Karlsen RV, Tjønneland A, Johansen C, Frederik-sen K, Bidstrup P (2016). Physical activity and survival in breast cancer. European Journal of Cancer. 66: 67–74. https://doi.org/10.1016/j.ejca.20-16.07.010.


Beasley JM, Kwan ML, Chen WY, Weltzien EK, Kroenke CH, Lu W, Nechuta SJ, et al. (2012). Meeting the physical activity guidelines and survival after breast cancer: Findings from the after breast cancer pooling project. Breast Cancer Res Treat. 131(2):

-43. https://doi.org/10.1007/s10549-011-1770-1.


Borch KB, Braaten T, Lund E, Weiderpass E (2015). Physical activity before and after breast cancer diagnosis and survival - The Norwegian women and cancer cohort study. BMC Cancer. 15(1): 1–10. https://doi.org/10.1186/-s12885-015-1971-9.


Bertram LAC, Stefanick ML, Saquib N, Natarajan L, Patterson RE, Bardwell W, Flatt SW, et al. (2011). Physical activity, additional breast cancer events, and mortality among early-stage breast cancer survivors: Find-ings from the WHEL study. Cancer Causes and Control, 22(3): 427–435. https://doi.org/10.1007/s10552-010-9714-3.


Bradshaw PT, Ibrahim JG, Khankari N, Cleveland RJ, Abrahamson PE, Ste-vens J, Satia JA, et al. (2014). Post-diagnosis physical activity and sur-vival after breast cancer diagnosis: The long island breast cancer study. Breast Cancer Research and Treatment. 145(3): 735–742. https://doi.org/10.1007/s10549-014-2966-y.


Chlebowski RT (2013). Nutrition and phy-sical activity influence on breast cancer incidence and outcome. Breast, 22(2): S30–S37. https://doi.org/10.-1016/j.breast.2013.07.006.


Friedenreich CM, Gregory J, Kopciuk KA, Mackey JR, Courneya KS (2009). Prospective cohort study of lifetime physical activity and breast cancer survival. Int J Cancer. 124(8): 1954–1962. https://doi.org/10.1002/ijc.24-155.


Garcia DO, Thomson CA (2014). Physical activity and cancer survivorship. Nutr Clin Prac. 29(6): 768–779. https://dx.doi.org/10.1177%2F0884533614551969.


Globocan Observatory. (2020). Breast Can-cer. Source: Globocan 2018. World Health Organization International Agency for Research on Cancer, 876, 2018–2019. http://gco.iarc.fr/today-%0Ahttps://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf accessed on September 2020.


Hellmann SS, Thygesen LC, Tolstrup JS, Gronbaek M (2010). Modifiable risk factors and survival in women diag-nosed with primary breast cancer: Results from a prospective cohort study. European J Cancer Prev. 19(5): 366–373. https://doi.org/10.1097/C-EJ.0b013e32833b4828.


Ibrahim EM, Al-Homaidh A (2011). Physical activity and survival after breast cancer diagnosis: Meta-analysis of published studies. Med Oncol. 28(3): 753–765. https://doi.org/10.1007/s1-2032-010-9536-x.


Irwin ML, McTiernan A, Manson JAE, Thomson CA, Sternfeld B, Stefanick ML, Wactawski-Wende J, et al. (2011). Physical activity and survival in postmenopausal women with breast cancer: Results from the women’s health initiative. Cancer Prevention Research. 4(4): 522–529. https://doi.org/10.1158/1940-6207.-CAPR-10-0295.


Jung AY, Behrens S, Schmidt M, Thoene K, Obi N, Husing A, Benner A, Steindorf K, Chang-Claude J (2019). Pre-to postdiagnosis leisure-time physical activity and prognosis in postmeno-pausal breast cancer survivors. Breast Cancer Research. 21(1): 1–11. https://doi.org/10.1186/s13058-019-1206-0.


Kementerian Kesehatan RI (2017). Ren-cana aksi nasional penyakit tidak menular (National action plan for non-communicable diseases) 2015-2019. Kementerian Kesehatan RI.


Maliniak ML, Patel AV, McCullough ML, Campbell PT, Leach CR, Gapstur SM, Gaudet MM (2018). Obesity, physical activity, and breast cancer survival among older breast cancer survivors in the cancer prevention study-II nu-trition cohort. Breast Cancer Research and Treatment. 167(1): 133–145. https://doi.org/10.1007/s10549-017-4470-7.


Murti B (2018). Prinsip dan Metode Riset Epidemiologi. Edisi ke 5 (Epidemio-logical Research Principles and Me-thods. 5th edition). Surakarta: Pro-gram Studi Ilmu Kesehatan Masyarakat.


Speck RM, Courneya KS, Mâsse LC, Duval S, Schmitz KH (2010). An update of controlled physical activity trials in cancer survivors: A systematic review and meta-analysis. J Cancer Surv. 4(2): 87–100. https://doi.org/10.100-7/s11764-009-0110-5.


Sternfeld B, Weltzien E, Quesenberry CP, Castillo AL, Kwan M, Slattery ML, Caan BJ (2009). Physical activity and risk of recurrence and mortality in breast cancer survivors: Findings from the LACE study. Cancer Epide-miology Biomarkers and Prevention. 18(1): 87–95. https://doi.org/10.1158-/1055-9965.EPI-08-0595.


Troeschel AN, Leach CR, Shuval K, Stein KD, Patel AV (2018). Physical activity in cancer survivors during “Re-Entry” following cancer treatment. Prevent-ing Chronic Disease. 15(5): 1–10. https://doi.org/10.5888/pcd15.170277.


WHO (2020). Breast cancer survival. World Health Organization. https://www.cancer.org/cancer/breast-cancer/-understanding-a-breast-cancer-diag-nosis/breast-cancer-survival-rates.-html.


WHO (2020). Physical activity. World Health Organization. https://www.who.int/news-room/fact-sheets/de-tail/physical-activity.

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