User

Comparison of Hemoglobin Concentration Before and After Trichuriasis Treatment with Albendazole among Primary School Children

Novreka P Sipayung, Nurfida Arrasyid, Ayodhia P Pasaribu

Abstract

Background: Trichuriasis is a soil transmitted helminth that causes anemia and growth disturbance in children. This study aimed to compare hemoglobin concentration before and after Trichuriasis treatment with albendazole among primary school children.

Subjects and Method: This was an experimental study with before and after quasi experiment design. This study was conducted at Medan Tembung Primary School, Medan, North Sumatera, from March to June, 2015. A total of 63 children were selected for this study. Blood sample was taken for hemoglobin concentration examination before and after the administration of albendazole. The treatment consisted of 400 mg albendazole that was administered in single dose 0nce a day for 3 days, both for single and mixed infection.

Results: The prevalence of Trichuriasis among the school children under study was 33.3% (126/ 378), which was consisted of 37 children with single infection and 26 children with mixed infection. Albendazole increased hemoglobin concentration with mean= 11.88 g/dl; SD=1.26 before treatment and mean=12.53 g/dl; SD= 1.37 after treatment, among children with single infection, and it was statistically significant (p= 0.002). Albendazole increased hemoglobin concentration with mean= 11.69 g/dl; SD=1.04 before treatment and mean=12.36 g/dl; SD= 1.06 after treatment, among children with mixed infection, and it was statistically significant (p= 0.001).

Conclusion: Albendazole is effective in increasing hemoglobin concentration among school children with anemia that is caused by Trichuriasis infection. 

Keywords: helminthiasis, trichuriasis, hemoglobin, anemia, albendazole, school children

Correspondence: Novreka Pratiwi Sipayung. Department Parasitology, Faculty of Medicine, HKBP Nommensen University, Medan. Email: ega_efq@yahoo.com. Mobile: 085261145049.

Indonesian Journal of Medicine (2016), 1(4): 201-208
https://doi.org/10.26911/theijmed.2017.02.01.08

Full Text:

PDF

References

Anggraini R, Dimyati Y, Bidasari L, Pasaribu S, Lubis CP (2005). Association between Soil Transmitted Helminthiasis and Haemoglobin Concentration in Primary School Children. Paediatrica Indonesiana 45: 1-2. Available from http://repository.usu.ac.id/ handle/123456789/18132.

Bambang PH, Sutaryo, Ugrasena IDG (2006). Buku Ajar Hematologi Onkologi Anak. Cetakan kedua. Badan Penerbit IDAI: 30-35.

Blumental DS, Schultz MG (1976). Effects of Ascaris infection on nutriational status in childrean. Am J Trop Med Hyg 25: 682-90.

Chaudhry ZH, Fazal M, Malik MA (2004). Epidemiological factors affecting prevalence of intestinal parasites in children of Muzaffarabad district. Pakistan J Zool 36: 267-271.

Dinas Kesehatan Provinsi Sumatera Utara. 2013. Profil Kesehatan Provinsi Sumatera Utara.

Greenberg ER, Cline BL (1979). Is trichuriasis associated with iron deficiency anemia Am J Trop Med Hyg 28: 770-2.

Janice VN, Vicente Y, Belizario Jr, Florencia GC (2014). Determination of soiltransmitted helminth infection and its association with hemoglobin levels among Aeta school children of Katutubo Village in Planas, Porac, Pampanga Philippine Science Letters 7 (1).

Kirwan P, Asaolu SO, Abiona TC, Jackson AL, Smith HV, Holland CV (2009). Soil transmitted helminth infections in Nigerian children aged 0-25 months. Journal of Helminthology: 1–6.

Nallam NR, Paul I, Gnanamani G (1998). Anemia and hypoalbuminemia as an adjunct to soil transmitted helminthiasis among slum school children in Visakhapatnam. South India, Asia Pasific J Clin Nutr 7: 164-169.

Oguntibeju OO (2003). Parasitic infection and anemia: the prevalence in a rural hospital setting. JIACM: 210-212.

Robertson LJ, Crompton DWT, Nesheim MC (1992). Hemoglobin concentrarion and concomitant infections of hookworm and Trichuris trichiura in Panamanian primary school children. Transactions of the Royal Society of Tropical Medicine and Hygiene.

Smith HM, De Kaminsky RG, Niwas S, Soto RJ, Jolly PE (2001). Prevalence and intensity of infections of Ascaris lumbricoides dan Trichuris trichiura and associated sociodemographic variables in four rural Honduran communities. Mem Inst Oswaldo Cruz, Rio de Janeiro 96: 303-14.

Stoltzfus RJ, Albonico, Chwaya M, Savioli L, Tielsch J, Schulze K (1996). Hemoquant determination of hookworm related blood loss and its in iron deficiency in African children. Am J Trop Med Hyg 55: 399-404.

Sutanto I, Ismid SI, Sjarifuddin KP, Sungkar S (2008). Parasitologi Kedokteran. Edisi Keempat. Jakarta: Balai Penerbit FK UI. Cetakan 2: 22.

Tekeste Z, Belyhun Y, Gebrehiwot A, Moges B, Workineh M, Ayalew G (2013). Epidemiology of intestinal schistosomiasis and soil transmitted helminthiasis among primary school children in Gorgora, Northwest Ethiopia.Asian Pac J Trop Dis 3(1): 61-64.

Vercruysse J, Behnke JM, Albonico M, Shaali M, Angebault C, Bethony MJ (2011). Assessment of the antihelmintic efficacy of albendazole in school children in seven countries where soiltransmitted helminths are endemic. PLoS Negl Trop Dis 5.

Yunus R (2008). Keefektifan Albendazole Pemberian Sekali Sehari Selama 1,2 Dan 3 Hari Dalam Menanggulangi Infeksi Trichuris trichura pada Anak Sekolah Dasar di Kecamatan Medan Tembung. Medan. Available from http: //repository.usu.ac.id/handle/123456789/6244.

Refbacks

  • There are currently no refbacks.