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Association between Resistin and High Sensitive Troponin I in St Elevation Myocardial Infarction and Systolic Heart Failure

Trisulo Wasyanto, Laurent Febrilia

Abstract

Background: Nearly half of all patients with acute myocardial infarction (AMI) have left ventri­cular systolic dysfunction and one-third have symptoms of heart failure (HF). In patients with AMI the resistin level correlated inversely with left ventricular ejection fraction (LVEF). Increased levels of high sensitive (hs) troponin I are associated with poorer prognosis. This study aimed to deter­mine the association between levels of resistin and hs troponin I in ST elevation myocardial infarc­tion (STEMI) patients with systolic HF.

Subjects and Method: This was a cross-sectional study was conducted at Dr. Moewardi Gene­ral Hospital, Surakarta, from April 1 to May 31, 2018. A sample of 32 patients who admitted which diagnosed with STEMI was selected for this study. They were divided into two group according to result of LVEF measurement, LVEF < 40% and LVEF ≥ 40%. Blood examination and transthoracic echocardiography were performed to all patients. Correlation test using partial and multiple correlation test. To different 2 mean using Mann Whitney test.

Results: Mean of patient age was 59.5 years old. Resistin decreased LVEF (r= -0.41; p= 0.009), and it was statistically significant. Hs troponin I decreased LVEF (r= -0.25; p= 0.081), but it was marginally significant. Resistin level and hs troponin I increased LVEF (r= 0.47; p= 0.025), and it statistically significant.

Conclusion: There was an association between resistin and hs troponin I level together in STEMI patients with systolic HF. There was an association of resistin levels in STEMI patients with systolic HF. There was no association of hs troponin I levels in STEMI patients with systolic HF.

Keywords: Resistin, hs troponin I, STEMI, systolic heart failure.

Correspondence: Trisulo Wasyanto. Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Sebelas Maret / Dr. Moewardi Hospital. Jl. Kol. Sutarto 132, Surakarta 57126, Central Java, Indonesia. Email: trisulo.wasyanto@gmail.com.

Indonesian Journal of Medicine (2019), 4(4): 346-354
https://doi.org/10.26911/theijmed.2019.04.04.07

 


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References

Bonaca M, Scirica B, Sabatine M, Dalby A, Spinar J, Murphy SA, Jarolim P, Braunwald E, Morrow DA (2010). Prospective evaluation of the prognostic implications of improved assay performance with a sensitive assay for cardiac Troponin I. J Am Coll Cardiol. 55: 2118-25. doi: 10.1016/j.jacc.2010.01.044.


Chu S, Ding W, Li K, Pang Y, Tang C (2008). Plasma resistin associated with myocardium injury in patients with acute coronary syndrome. Circ J. 72: 1249–53.


Doenst T, Nguyen TD, Abel ED (2013). Cardiac Metabolism in Heart FailureImplications beyond ATP production. Circulation. 113(6): 709–24. doi: 10.1161/CIRCRESAHA.113.300376.


Erer HB, Sayar N, Guvenc TS, Aksaray S, Yilmaz H, Altay S, Turer A, Oz TK, et al. (2014). Prognostic Value of Serum Resistin Levels in Patients with Acute Myocardial Infarction. Kardiol Pol. 72(2): 181–6. doi: 10.5603/KP.a2013.0086.


Fontana A, Spadaro S, Copetti M, Spoto B, Salvemini L, Pizzini P, Frittitta L, Mallamaci F, et al. (2015). Association between resistin levels and all-cause and cardiovascular mortality: A new study and a systematic review and meta-analysis. PlosOne. 10(3): E0120419. doi: 10.1371/journal.pone.0120419.


Gencer B, Auer R, Rekeneire N, et al. (2016). Association between resistin levels and cardiovascular disease events in older adults: the health, aging and body composition study. J Atherosclerosis. (245): 181-186. doi:10.1016/j.atherosclerosis.2015.12.004.


Kunnari A (2008). Genetic, Epidemiological and Cell Culture Studies on Human Resistin. http://herkules.oulu.fi/isbn9789514289477/.


Layland J, Solaro RJ, Shah AM (2005). Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res. 66(1): 12-21. Doi: https://doi.org/10.1016/j.cardiores.2004.12.022.


Mahajan VS, Jarolim P (2011). How to Interpret elevated cardiac troponin levels. Circulation, 124(21): 2350-4. https://doi.org/10.1161/CIRCULATIONAHA.111.023697


Menzaghi C, Marucci A, Antonucci A, De Bonis C, Moreno LO, Salvemini L, Copetti M, Trischitta V, Di Paola R (2017). Suggestive evidence of a multicytokine resistin pathway in humans and its role on cardiovascular events in high-risk individuals. Nature. 7: 44337. Doi: 10.1038/srep44337.


Morrow DA, Antman EM (2009). Evaluation of high-sensitivity assays for cardiac troponin. Clin Chem. 55(1): 5-8. doi: 10.1373/clinchem.2008.117218


Mukherjee JT, Beshansky JR, Ruthazer R, Alkofide H, Ray M, Kent D, Manning WJ, Huggins GS, Selker HP (2016). In hospital measurement of left ventricular ejection fraction and one year outcomes in acute coronary syndromes: Results from The IMMEDIATE Trial. Cardiovasc Ultrasound. 14(1): 29. doi: 10.1186/s12947-016-0068-1.


Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, et al. (2016). 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European society of cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 37(27): 2129-2200. doi: 10.1093/eurheartj/ehw128


Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD (2012). Third universal definition of myocardial infarction. J Am Coll Cardiol. 60: 1581-9. https://doi.org/10.1161/CIR.0b013e31826e1058.


Zhang YX, Li YX, Yu L, Zhou L (2017). Association between serum resistin concentration and hypertension: A systematic review and meta-analysis. Oncotarget. 8(25): 41529-37. doi: 10.18632/oncotarget.17561.


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