Effect of Purple Sweet Potato (Ipomoea Batatas L.) Extract on Glutathione Peroxidase (GPx) Activities in Hepatic House Mice (Mus musculus) After Maximum Physical Exercise

Ayu Elvana, Herla Rusmarilin, Ramlan Silaban, Rika Nailuvar Sinaga


Background: Physical exercise can improve antioxidant defense system of organis. But long and heavy exercise can disrupt the balance of oxidant-antioxidant. Low glutathione peroxidase is associated with free radicals. Plant purple sweet potatoes (Ipomoea batatas L.) contain anthocyanins high enough that act as antioxidants. This stu­dy aimed to determine the effect of extracts of tubers of purple sweet potato (Ipomoea Batatas L.) on the activity of glutathione peroxidase (GPx) liver of mice (Mus Musculus) treated with maximal physical exercise.

Subjects and Method: This was a true experimental study. This conducted with the design of the control group post-test only in vivo on 24 white male mice (Mus musculus), DD Webster strain. Da­ta analysis was using SPSS software 19. Statistical testing decision taken 5% significance level (p=0.05).

Results: The results showed that the average enzyme activity of GPx in the P5 is the highest enzyme activity GPx (mean=19:39 ± SD=7:06, p=0.024), which means there are significant differ­rences in the enzyme activity of GPx values between groups.

Conclusion: This study showed that the extract could increase the activity of GPx hepatic enzyme­es mice significantly.

Keywords: physical exercise maximum, free radicals, purple sweet potato, anthocyanin, GPx

Correspondence: Ayu Elvana. School of Health Sciences (STIKes) Siti Hajar, Medan, Indonesia.

Indonesian Journal of Medicine (2016), 1(2): 116-120

Full Text:



Agarwal A, Gupta S, Sharma RK (2005). Role of oxidative stress in female reproduction. Biol Reprod Endrocinol.

Chen CY, Holtzman GI, Bakhit RM (2002). Highgenistin isoflavone supplementation modulated and Increased erythrocyte antioxidant enzymes in rats undergoing endurance running one session of exhausting exercisea pilot study. Pakistan Journal of Nutrition. 1(1).

Cooper K (2001). Healthy without drugs. Four steps antioxidant revolution that changed your life. Bandung: Kaifa.

MR Daniel, Dragomir C, Stelian S (2010). The effect of acute physical exercise on liver and kidney in the Wistar rat. Romanian biotechnological Letters 15 (3), Supplement. Copyright © 2010 University of Bucharest.

Department of Health (2014). Improve community health status through exercise. Accessed on March 24, 2014.

Escribano BM (2010). Effects of an aerobic training program on oxidative stress biomarkers in bulls. Veterinarni Medicina, 55, 2010 (9): 422-428.

Hou Zhaohua, Qin, Peiyou, Ren, Guixing (2010). Effect of anthocyanin rich extract from black rice (Oryza sativa l. Japonica) on chronically alcohol induced liver damage in rats. J. Agric. Food Chem. 2010, 58, 3191-3196. DOI: 10.1021 / jf904407x

Jawi IM, Suprapta DN, Sutirtayasa IWP (2007). The antioxidant effect of extracts of tubers of purple sweet potato (Ipomoea batatas L) of the liver after physical activity with up to see the AST and ALT levels in the blood of mice. Dexa Media. 20 (3).

Five DF (2001). Swimming training induces adaptations to liver mitochondrial oxidative stress in rats submitted to repeated bouts of exhaustive swimming. PLoS ONE. 8(2): e55668.

Musthofiyah H (2008). Effect of papaya (Carica papaya) on levels of transaminase enzymes guttergpt and histology of liver of mice (Mus musculus) induced karbontetraklorida (CCl4). Thesis, Malang: The Malang Islamic University, Biology, Faculty of Science and Technology.

Sastradipradja D (2014). Work physiology in animals sports. Denpasar: Udayana University, Department of Food Science Faculty of Animal Husbandry.

Simanjuntak K (2012). The role of antioxidant flavonoids in improving health. Jakarta, BINA WIDYA, 23(3): 135-140

Sugianto NL (2011). Giving juice red pomegranate (Punica granatum) can increase blood levels of glutathione peroxidase in mice (Mus musculus) with a maximum of physical activity. Thesis, Denpasar: Udayana University.

Suprapta DN (2004). Study aspects of breeding, cultivation and utilization of tubers as an alternative food source. Research Report. BAPEDA cooperation with the Faculty of Agriculture Bali Province UNUD.

Thirumalai T, Therasa SV, EK Elumalai, David E (2011). Intense and exhaustive exercise induced oxidative stress in skeletal muscle. Asian Pacific Journal of Tropical Disease. 63-66

Winarsi H (2007). Natural Antioxidants and Free Radicals. Yogyakarta. Publisher Canisius.


  • There are currently no refbacks.