Comparison of Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) between Normal and Severe Pre-eclampsia in Pregnant Women, Medan, Indonesia

Rebecca Rumesty Lamtiar, Erna Mutiara, Sarma N Lumban Raja


Background: The pathogenesis of pre-eclampsia as a primary cause of mortality among pregnant women remains unclear. It was suggested that angiogenic factors such as Soluble fms-Like Tyrosine Kinase-1 (SFLT-1) play an important role in the causal mechanism of pre-eclampsia/ eclampsia. This study aimed to compare the SFLT-1 level in pre-eclampsia/eclampsia in pregnant women with that in normotensive pregnant women.

Subjects and Method: This was an analytic observational conducted at three hospitals: Haji Adam Malik, Pirngadi, and Sundari Hospitals, Medan, Indonesia, from September to December 2014. A total sample of 60 pregnant women of the third trimester, including those with severe pre-eclampsia/eclampsia and normotensive women, was selected for this study. The level of serum SFLT-1 was measured by ELISA method. The difference in mean of serum SFLT-1 levels between the two groups was tested by Mann-Whitney.

Results: The mean of serum SFLT-1 level in women with preeclampsia was higher (mean=1692.69pg/ml; SD=540.64) than that in normotensive women (mean=1348.52pg/ml; SD=649.83). This difference was statistically significant (p=0.040).

Conclusion: Level of serum SFLT-1 in women with severe pre-eclampsia/eclampsia is significantly higher than that of normotensive women.

Keywords: serum SFLT-1, pre-eclampsia, pregnant women

Correspondence: Rebecca Rumesty Lamtiar. Department of Physiology, Faculty of Medicine, HKBP Nommensen University, Medan.

Indonesian Journal of Medicine (2016), 1(2): 84-89

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Alice W, Sarosh R, S Ananth K (2008). Preeclampsia: The Role of angiogenic Factors in Its Pathogenesis. Physiology, 24: 147-158

Andraweera PH, Dekker GA, C Roberts T (2012). The Vascular Endothelial Growth Factor Family in Adverse Pregnancy Outcomes. Human Reproduction Update, 18: 436-457

Eiland E, Nzerue C, Faulkner M (2012). Review Article Preeclampsia. Journal of Pregnancy, 1-7.

Karumanchi SA, Epstein MH (2007). Placental ischemia and Soluble fms-Like Tyrosine Kinase 1: Cause or Consequence of Preeclampsia. Kidney International, 71: 959-961

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein MH, Romero Roberto, Thadhani Ravi, Karumanchi SA (2004). Soluble Endoglin and Other Circulating antiangiogenic Factors in Preeclampsia. The New England Journal of Medicine, 355: 992-1005

Markus S, Dogan C, Canan B, Ulrich K, Gllhaus A, Rainer K, Bauer SK. (2009). Placental Growth Factor: A Predictive Marker for Pre-eclampsia. Gynakol Geburt shilfliche Rundsch, 49: 94-99

Marni J, Natasha N, Christine LR, Ruth H, Jonathan M, Ashton M, Anthony W. (2011). Levels of Soluble fmslik Tyrosine Kinase and One in the First Trimester of Pregnancy Outcomes: A Systematic Review. Reproductive Biology and Endrocinology, 9: 1-8

Matsubara K, Yuko M, Ito M. (2009). The Utility of Vascular Dysfunction Studies in The Prediction and Prevention of Preeclampsia: A Historical Review. Vascular Disease Prevention, 6: 163-169

Maynard SE, Min JY, Merchan J, Lim Kee Rights, Li Jianyi, Mondal S, Libermann TA, JP Morgan, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, and Karumanchi SA. (2003). Excess Placental Soluble fms-Like Tyrosine Kinase 1 (SFLT-1) may Contribute to Endothelial Dysfunction, Hypertension and Proteinuria in Preeclampsia. J. Clin. Invest, 1(11): 649-658

Ministry of Health. (2008). Maternal Mortality. Downloaded from:

WHO Ministry of Health. (2012). Trends in Maternal Mortality from 1992 to 2012 in 2012 IDHS.

MoH, (2011). The Indonesia Health Profile Data. Downloaded from

Murphy SR, Lamarca BBD, Parrish M, Cockrell K, Granger JP. (2013). Control of Sluble Fms tyrosine Like-1 (SFLT-1) Production Response to Placental ischemia/ hypoxia: Role of Tumor Necrosis Factorα. American Journal Physioregul integr Comp Physiol.; 304: R130-R135

Mutter WP, Karumanchi SA. (2008). Molecular Mechanisms of Preeclampsia. Microvascular Research, 75: 1-8.

Odegård RA, Vatten LJ, Nilsen ST, Vesen KA, Austgulen R (2000). Risk factors and clinical manifestations of preeclampsia. BJOG; 107: 1410-6.

The National Population and Family Planning (2012). The Indonesian Demographic and Health Survey. Jakarta; Indonesia; 213 things.

UNICEF (2012). Summary of Maternal and Child Health Study. Jakarta: 1-6.

Verlohren S, Herraiz I, Lapaire O, Schlembach D, Moertl M, Zeisler Harald, Calda P, Holzgreve W, A Galindo, Engels T, Denk B, Stepan H. (2011). The SFLT-1 / PlGF ratio in Different Types of hypertensive. The New England Journal of Medicine, 1(5): 9-15.


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