Effect of Purple Sweet Potato (Ipomoea Batatas L.) on Reducing Renal Tissue Damage of House Mice (Mus Musculus L.) After Excessive Physical Exercise

Rika Nailuvar Sinaga, Herla Rusmarilin, T.Helvi Mardiani, Ayu Elvana


Background:  Heavy  physical exercise can reduce blood flow  and metabolism in kidney that eventually release free radicals. The free radicals can form oxydative stress and damage renal tissue. Exogenous antioxydant administration is usually recommended to minimize the renal tissue damage.  This study aimed to examined the effect of purple sweet potato  (Ipomoiea batatas  L.) extract on renal tissue damage  in mice  (mus musculus L.) after heavy physical exercise.

Subjects and Method: This was a randomized controlled trial with post test only control design. The study subjects included twenty four male white mice with DD Webster strain. These mice were divided into six  groups.  After undergoing excessive swimming  exercises that lasted forteen days, purple sweet potato extract was given to the experimental group.  There were three experimental groups receiving three different doses of purple sweet potato. The mice kidney was taken as sample for microscopic examination  to determine the extent of tissue damage. Difference in  renal  tissue damage was tested by Kruskal-Wallis.

Results: Microscopic examination showed statistically significant difference in tissue damage both in  right (p=0.001) and left (p=0.036)  kidneys, between  study  groups.  The experimental groups showed less damaged than control group. Conclusion:  Purple sweet potato  (Ipomoiea batatas L)  can lessen renal damage in male white mice (Mus musculus L) undergoing excessive physical exercise.
Keywords: purple sweet potato (Ipomoiea batatas L), renal tissue damage mice. 

Corespondance: Rika Nailuvar Sinaga. Faculty of Sport Science, Medan University. Email:

Indonesian Journal of Medicine (2016), 1(1): 76-83

Full Text:



Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O (2012). Oxidative Stress and Antioxidant Defense. WAO Journal: 9-19.

Bucioli SA, Abreu LC, Valenti VE, Leone C, Vannucchi H (2011). Effects of vitamin E supplementation on renal nonenzymatic antioxidants in young rats submitted to exhaustive exercise stress. BMC Complementary and Alternative Medicine, 11:133.

Daniel RM, Dragomir C, Stelian S (2010). The effect of acute physical exercise on liver and kidney in the Wistar rat. Romanian Biotechnological Letters, 15(3):51-55.

Kocer G, Senturk UK, Kuru O, Gunduz F (2008). Potential sources of oxidative stress that induce postexercise proteinuria in rats. J Appl Physiol, 104: 1063-1068.

Kumar, Abbas, Fausto, Mitchell (2007). Robbins Basic Pathology (8th ed.). Philadelphia : Elsevier.

Manurung RD (2011). Tesis : Manfaat Pemberian Madu terhadap Perubahan Ureum dan Kreatinin serta Makroskopik Ginjal dan Histopatologi Tubulus Proksimal Ginjal Mencit (Mus musculus L) Jantan yang diberi Rhodamin B. Universitas Sumatera Utara. Medan.

Nangaku M (2006). Chronic Hypoxia and Tubulointerstitial Injury: A Final Common Pathway to End-Stage Renal Failure. American Society of Nephro-logy,17:17-25.

Okolow MP, Dziegiel P, Gomulkiewicz A, Kisiela D, Krajewska BD, Jethon Z, Carraro U (2006). Exerciseinduced apoptosis in rat kidney is mediated by both angiotensin II AT1 and AT2 receptors. Histology and Histopathology, 21:459-466.

Pojer E, Mattivi F, Johnson, Stockley CS (2013). The Case for Anthocyanin Consumption to Promote Human Health: A Review. Institute of food technologists, 12:483-508.

Prior RL (2003). Fruits and vegetables in the prevention of cellular oxidative damage. Am J Clin Nutr, 78:570S-8S.

Radak Z, Zhao Z, Koltai E, Ohno H, Atalay M (2013). Oxygen Consumption and Usage During Physical Exercise: The Balance Between Oxidative Stress and ROS-Dependent Adaptive Signaling. Antioxidants & Redox Signaling, 18(10): 1208-1246.

Richana N (2013). Menggali potensi ubi kayu dan ubi jalar. Edisi kedua. Bandung: Nuansa Cendikia.

Sreedevi A, Pavani B (2012). Effect of anthocyanin fraction on cisplatininduced nephrotoxicity. IJRAP, 3(4):587-590.

Urso ML, Clarkson PM (2003). Oxidative stress, exercise, and antioxidant supplementation.Toxicology;189(12):41-54.


  • There are currently no refbacks.